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dc.contributor.authorLlewellyn, Aen
dc.contributor.authorFoey, Aen
dc.date.accessioned2018-10-24T08:58:06Z
dc.date.available2018-10-24T08:58:06Z
dc.date.issued2017-10-23en
dc.identifier.urihttp://hdl.handle.net/10026.1/12602
dc.description.abstract

There is a growing body of evidence documenting probiotic bacteria to have a beneficial effect to the host through their ability to modulate the mucosal immune system. Many probiotic bacteria can be considered to act as either immune activators or immune suppressors, which have appreciable influence on homeostasis, inflammatory- and suppressive-immunopathology. What is becoming apparent is the ability of these probiotics to modulate innate immune responses via direct or indirect effects on the signaling pathways that drive these activatory or suppressive/tolerogenic mechanisms. This review will focus on the immunomodulatory role of probiotics on signaling pathways in innate immune cells: from positive to negative regulation associated with innate immune cells driving gut mucosal functionality. Research investigations have shown probiotics to modulate innate functionality in many ways including, receptor antagonism, receptor expression, binding to and expression of adaptor proteins, expression of negative regulatory signal molecules, induction of micro-RNAs, endotoxin tolerisation and finally, the secretion of immunomodulatory proteins, lipids and metabolites. The detailed understanding of the immunomodulatory signaling effects of probiotic strains will facilitate strain-specific selective manipulation of innate cell signal mechanisms in the modulation of mucosal adjuvanticity, immune deviation and tolerisation in both healthy subjects and patients with inflammatory and suppressive pathology.

en
dc.languageengen
dc.language.isoengen
dc.subjectcytokinesen
dc.subjectdendritic cellsen
dc.subjectepithelial cellsen
dc.subjectimmunomodulationen
dc.subjectinflammationen
dc.subjectinnateen
dc.subjectmacrophagesen
dc.subjectneutrophilsen
dc.subjectprobioticsen
dc.subjectsignalingen
dc.subjectEpithelial Cellsen
dc.subjectGastric Mucosaen
dc.subjectGastrointestinal Microbiomeen
dc.subjectHomeostasisen
dc.subjectHumansen
dc.subjectImmunity, Innateen
dc.subjectImmunity, Mucosalen
dc.subjectImmunomodulationen
dc.subjectInflammasomesen
dc.subjectIntestinesen
dc.subjectKiller Cells, Naturalen
dc.subjectMacrophagesen
dc.subjectNeutrophilsen
dc.subjectProbioticsen
dc.subjectSignal Transductionen
dc.titleProbiotic Modulation of Innate Cell Pathogen Sensing and Signaling Events.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/29065562en
plymouth.issue10en
plymouth.volume9en
plymouth.publication-statusPublished onlineen
plymouth.journalNutrientsen
dc.identifier.doi10.3390/nu9101156en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Biomedical Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeSwitzerlanden
dcterms.dateAccepted2017-10-09en
dc.identifier.eissn2072-6643en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.3390/nu9101156en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-10-23en
rioxxterms.typeJournal Article/Reviewen


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