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dc.contributor.authorBassendine, MF
dc.contributor.authorNielsen, SU
dc.contributor.authorBridge, SH
dc.contributor.authorFelmlee, DJ
dc.contributor.authorSheridan, DA
dc.contributor.authorPackard, CJ
dc.contributor.authorNeely, RD
dc.date.accessioned2018-10-15T07:59:55Z
dc.date.available2018-10-15T07:59:55Z
dc.date.issued2017-02
dc.identifier.issn2210-7401
dc.identifier.issn2210-741X
dc.identifier.urihttp://hdl.handle.net/10026.1/12522
dc.descriptionpublisher: Elsevier articletitle: Hepatitis C virus and atherosclerosis: A legacy after virologic cure? journaltitle: Clinics and Research in Hepatology and Gastroenterology articlelink: http://dx.doi.org/10.1016/j.clinre.2016.09.008 content_type: article copyright: © 2016 Elsevier Masson SAS. All rights reserved.
dc.description.abstract

Hepatitis C virus (HCV) is a major pathogen with approximately 3% of the world's population (over 170 million) infected. Epidemiological studies have shown HCV is associated with an increased risk of cardiovascular and cerebrovascular mortality as well as peripheral arterial disease. This is despite HCV inducing an ostensibly favourable lipid profile with accompanying low classical risk score for atherosclerosis (AS). We discuss possible factors involved in the aetiopathogenesis of atherosclerosis in chronic HCV and hypothesise that an important mechanism underlying the development of AS is the presence of circulating low-density immune complexes that induce an inflammatory response. We suggest that HCV particles may be inducing an antibody response to lipoproteins present in the lipoviral particles and sub-viral particles - a concept similar to the more general 'autoantibody' response to modified LDL. After virologic cure some AS risk factors will recede but an increase in serum cholesterol could result in progression of early atherosclerotic lesions, leaving a legacy from persistent HCV infection that has clinical and therapeutic implications.

dc.format.extent25-30
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoen
dc.publisherElsevier BV
dc.subjectAtherosclerosis
dc.subjectCoronary Artery Disease
dc.subjectDisease Progression
dc.subjectHepacivirus
dc.subjectHepatitis C
dc.subjectHumans
dc.subjectPrognosis
dc.subjectRisk Factors
dc.subjectSeverity of Illness Index
dc.subjectViral Load
dc.titleHepatitis C virus and atherosclerosis: A legacy after virologic cure?
dc.typejournal-article
dc.typeReview
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/27840032
plymouth.issue1
plymouth.volume41
plymouth.publication-statusPublished
plymouth.journalClinics and Research in Hepatology and Gastroenterology
dc.identifier.doi10.1016/j.clinre.2016.09.008
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeFrance
dcterms.dateAccepted2016-09-22
dc.identifier.eissn2210-741X
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1016/j.clinre.2016.09.008
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-02
rioxxterms.typeJournal Article/Review


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