Validation of the UNC OCT Index for the Diagnosis of Early Glaucoma
dc.contributor.author | Mwanza, J-C | |
dc.contributor.author | Lee, G | |
dc.contributor.author | Budenz, DL | |
dc.contributor.author | Warren, JL | |
dc.contributor.author | Wall, M | |
dc.contributor.author | Artes, Paul | |
dc.contributor.author | Callan, TM | |
dc.contributor.author | Flanagan, JG | |
dc.date.accessioned | 2018-10-05T11:45:48Z | |
dc.date.available | 2018-10-05T11:45:48Z | |
dc.date.issued | 2018-04-03 | |
dc.identifier.issn | 2164-2591 | |
dc.identifier.issn | 2164-2591 | |
dc.identifier.other | ARTN 16 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/12463 | |
dc.description.abstract |
PURPOSE: To independently validate the performance of the University of North Carolina Optical Coherence Tomography (UNC OCT) Index in diagnosing and predicting early glaucoma. METHODS: Data of 118 normal subjects (118 eyes) and 96 subjects (96 eyes) with early glaucoma defined as visual field mean deviation (MD) greater than -4 decibels (dB), aged 40 to 80 years, and who were enrolled in the Full-Threshold Testing Size III, V, VI comparison study were used in this study. CIRRUS OCT average and quadrants' retinal nerve fiber layer (RNFL); optic disc vertical cup-to-disc ratio (VCDR), cup-to-disc area ratio, and rim area; and average, minimum, and six sectoral ganglion cell-inner plexiform layer (GCIPL) measurements were run through the UNC OCT Index algorithm. Area under the receiver operating characteristic curve (AUC) and sensitivities at 95% and 99% specificity were calculated and compared between single parameters and the UNC OCT Index. RESULTS: Mean age was 60.1 ± 11.0 years for normal subjects and 66.5 ± 8.1 years for glaucoma patients (P < 0.001). MD was 0.29 ± 1.04 dB and -1.30 ± 1.35 dB in normal and glaucomatous eyes (P < 0.001), respectively. The AUC of the UNC OCT Index was 0.96. The best single metrics when compared to the UNC OCT Index were VCDR (0.93, P = 0.054), average RNFL (0.92, P = 0.014), and minimum GCIPL (0.91, P = 0.009). The sensitivities at 95% and 99% specificity were 85.4% and 76.0% (UNC OCT Index), 71.9% and 62.5% (VCDR, all P < 0.001), 64.6% and 53.1% (average RNFL, all P < 0.001), and 66.7% and 58.3% (minimum GCIPL, all P < 0.001), respectively. CONCLUSIONS: The findings confirm that the UNC OCT Index may provide improved diagnostic perforce over that of single OCT parameters and may be a good tool for detection of early glaucoma. TRANSLATIONAL RELEVANCE: The UNC OCT Index algorithm may be incorporated easily into routine clinical practice and be useful for detecting early glaucoma. | |
dc.format.extent | 16-16 | |
dc.format.medium | Electronic-eCollection | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Association for Research in Vision and Ophthalmology (ARVO) | |
dc.subject | early glaucoma | |
dc.subject | optical coherence tomography | |
dc.subject | UNC OCT Index | |
dc.title | Validation of the UNC OCT Index for the Diagnosis of Early Glaucoma | |
dc.type | journal-article | |
dc.type | Journal Article | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000429062200010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 2 | |
plymouth.volume | 7 | |
plymouth.publication-status | Published | |
plymouth.journal | Translational Vision Science & Technology | |
dc.identifier.doi | 10.1167/tvst.7.2.16 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/School of Health Professions | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Health and Community | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2018-02-21 | |
dc.identifier.eissn | 2164-2591 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1167/tvst.7.2.16 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2018-04-03 | |
rioxxterms.type | Journal Article/Review |