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dc.contributor.authorvan Kampen, SC
dc.contributor.authorJones, R
dc.contributor.authorKisembo, H
dc.contributor.authorHouben, RMGJ
dc.contributor.authorWei, Y
dc.contributor.authorMugabe, FR
dc.contributor.authorRutebemberwa, E
dc.contributor.authorKirenga, B
dc.date.accessioned2018-09-25T09:55:37Z
dc.date.available2018-09-25T09:55:37Z
dc.date.issued2018-09-18
dc.identifier.issn1058-4838
dc.identifier.issn1537-6591
dc.identifier.urihttp://hdl.handle.net/10026.1/12417
dc.description.abstract

Background: People with pulmonary tuberculosis (TB) are at risk of developing chronic respiratory disorders due to residual lung damage. So far, the scope of the problem in high burden TB countries is relatively unknown. Methods: Chronic respiratory symptoms (cough and phlegm lasting >2 weeks) and radiological lung abnormalities were compared between adults with and without a history of TB among the general population of Uganda. Multivariable regression models were used to estimate odds ratios with adjustment for age, gender, smoking, education, setting and region. Random effects models accounted for village clustering effect. Results: Of 45,293 invited people from 70 villages, 41,154 (90.9%) participated in the survey. 798 had a history of TB and among them, 16% had respiratory symptoms and 41% x-ray abnormalities. Adjusted odds ratios showed strong evidence for individuals with a history of TB having increased risk of respiratory symptoms (OR=4·02, 95%CI: 3·25-4·96) and x-ray abnormalities (OR=17·52, 95%CI: 14·76-20·79); attributing 6% and 24% of the respective population risks. Conclusions: In Uganda, a history of TB was a strong predictor of respiratory symptoms and lung abnormalities, before older age and smoking. Eliminating TB disease could reduce the prevalence of chronic respiratory symptoms as much as eliminating smoking.

dc.format.extent1919-1925
dc.format.mediumPrint
dc.languageen
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.subjecttuberculosis
dc.subjectchronic respiratory disorders
dc.subjectepidemiology
dc.subjectprevalence survey
dc.subjectUganda
dc.titleChronic respiratory symptoms and lung abnormalities among people with a history of tuberculosis in Uganda: a national survey.
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/30239605
plymouth.issue11
plymouth.volume68
plymouth.publisher-urlhttp://dx.doi.org/10.1093/cid/ciy795
plymouth.publication-statusPublished
plymouth.journalClinical Infectious Diseases
dc.identifier.doi10.1093/cid/ciy795
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Engineering, Computing and Mathematics
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dc.publisher.placeUnited States
dcterms.dateAccepted2018-08-15
dc.rights.embargodate2019-9-18
dc.identifier.eissn1537-6591
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1093/cid/ciy795
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-09-18
rioxxterms.typeJournal Article/Review


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