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dc.contributor.authorCollord, Gen
dc.contributor.authorTarpey, Pen
dc.contributor.authorKurbatova, Nen
dc.contributor.authorMartincorena, Ien
dc.contributor.authorMoran, Sen
dc.contributor.authorCastro, Men
dc.contributor.authorNagy, Ten
dc.contributor.authorBignell, Gen
dc.contributor.authorMaura, Fen
dc.contributor.authorYoung, MDen
dc.contributor.authorBerna, Jen
dc.contributor.authorTubio, JMCen
dc.contributor.authorMcMurran, CEen
dc.contributor.authorYoung, AMHen
dc.contributor.authorSanders, Men
dc.contributor.authorNoorani, Ien
dc.contributor.authorPrice, SJen
dc.contributor.authorWatts, Cen
dc.contributor.authorLeipnitz, Een
dc.contributor.authorKirsch, Men
dc.contributor.authorSchackert, Gen
dc.contributor.authorPearson, Den
dc.contributor.authorDevadass, Aen
dc.contributor.authorRam, Zen
dc.contributor.authorCollins, VPen
dc.contributor.authorAllinson, Ken
dc.contributor.authorJenkinson, MDen
dc.contributor.authorZakaria, Ren
dc.contributor.authorSyed, Ken
dc.contributor.authorHanemann, COen
dc.contributor.authorDunn, Jen
dc.contributor.authorMcDermott, MWen
dc.contributor.authorKirollos, RWen
dc.contributor.authorVassiliou, GSen
dc.contributor.authorEsteller, Men
dc.contributor.authorBehjati, Sen
dc.contributor.authorBrazma, Aen
dc.contributor.authorSantarius, Ten
dc.contributor.authorMcDermott, Uen
dc.date.accessioned2018-09-19T14:26:36Z
dc.date.issued2018-09-10en
dc.identifier.issn2045-2322en
dc.identifier.urihttp://hdl.handle.net/10026.1/12383
dc.description.abstract

Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable recurrences and dismal outcomes. Here, we present an integrated analysis of the whole genome, transcriptome and methylation profiles of primary and recurrent anaplastic meningioma. A key finding was the delineation of distinct molecular subgroups that were associated with diametrically opposed survival outcomes. Relative to lower grade meningiomas, anaplastic tumors harbored frequent driver mutations in SWI/SNF complex genes, which were confined to the poor prognosis subgroup. Aggressive disease was further characterised by transcriptional evidence of increased PRC2 activity, stemness and epithelial-to-mesenchymal transition. Our analyses discern biologically distinct variants of anaplastic meningioma with prognostic and therapeutic significance.

en
dc.format.extent13537 - 13537en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.titleAn integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/30202034en
plymouth.issue1en
plymouth.volume8en
plymouth.journalScientific Reportsen
dc.identifier.doi10.1038/s41598-018-31659-0en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dcterms.dateAccepted2018-08-16en
dc.rights.embargodate2018-09-21en
dc.identifier.eissn2045-2322en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1038/s41598-018-31659-0en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-09-10en
rioxxterms.typeJournal Article/Reviewen


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