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dc.contributor.authorSneyd, JRen
dc.contributor.authorRigby-Jones, AEen
dc.date.accessioned2012-11-09T22:02:21Z
dc.date.available2012-11-09T22:02:21Z
dc.date.issued2010-09en
dc.identifier.urihttp://hdl.handle.net/10026.1/1216
dc.description.abstract

Although well established in clinical practice, both propofol and midazolam have limitations. New hypnotics with different and potentially superior pharmacokinetics and pharmacodynamics are under development. These include the benzodiazepine receptor agonists CNS7056 and JM-1232 (-), the etomidate-based methoxycarbonyl-etomidate and carboetomidate, the propofol-related structures PF0713 and fospropofol, and THRX-918661/AZD3043. The basic pharmacology and the initial anaesthesia studies for each of these agents are reviewed. Several of the agents (CNS7056, THRX-918661/AZD3043, and fospropofol) have reached the stage of clinical trials. To be successful, novel compounds need to establish clear clinical advantages over existing agents and where possible the new agents are discussed in this context. Computer-controlled drug administration offers the ability to automatically implement infusion schemes too complex for manual use and the possibility of linking patient monitoring to administration to enhance patient safety.

en
dc.format.extent246 - 254en
dc.languageengen
dc.language.isoengen
dc.subjectAnesthesia, Intravenousen
dc.subjectAnesthetics, Intravenousen
dc.subjectDrug Delivery Systemsen
dc.subjectEtomidateen
dc.subjectGABA-A Receptor Agonistsen
dc.subjectHumansen
dc.titleNew drugs and technologies, intravenous anaesthesia is on the move (again).en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/20650920en
plymouth.issue3en
plymouth.volume105en
plymouth.publication-statusPublisheden
plymouth.journalBr J Anaesthen
dc.identifier.doi10.1093/bja/aeq190en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/00 Groups by role/Professional Services staff
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
dc.publisher.placeEnglanden
dc.identifier.eissn1471-6771en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1093/bja/aeq190en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.typeJournal Article/Reviewen


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