Show simple item record

dc.contributor.authorNooeaid, P
dc.contributor.authorHagen, Chris
dc.contributor.authorBeier, JP
dc.contributor.authorBoccaccini, AR
dc.date.accessioned2018-08-13T14:36:47Z
dc.date.available2018-08-13T14:36:47Z
dc.date.issued2012-10
dc.identifier.issn1582-4934
dc.identifier.issn1582-4934
dc.identifier.urihttp://hdl.handle.net/10026.1/12103
dc.description.abstract

Osteochondral tissue engineering has shown an increasing development to provide suitable strategies for the regeneration of damaged cartilage and underlying subchondral bone tissue. For reasons of the limitation in the capacity of articular cartilage to self-repair, it is essential to develop approaches based on suitable scaffolds made of appropriate engineered biomaterials. The combination of biodegradable polymers and bioactive ceramics in a variety of composite structures is promising in this area, whereby the fabrication methods, associated cells and signalling factors determine the success of the strategies. The objective of this review is to present and discuss approaches being proposed in osteochondral tissue engineering, which are focused on the application of various materials forming bilayered composite scaffolds, including polymers and ceramics, discussing the variety of scaffold designs and fabrication methods being developed. Additionally, cell sources and biological protein incorporation methods are discussed, addressing their interaction with scaffolds and highlighting the potential for creating a new generation of bilayered composite scaffolds that can mimic the native interfacial tissue properties, and are able to adapt to the biological environment.

dc.format.extent2247-2270
dc.format.mediumPrint
dc.languageen
dc.language.isoen
dc.publisherWiley
dc.subjectAnimals
dc.subjectBiocompatible Materials
dc.subjectBone Regeneration
dc.subjectBone and Bones
dc.subjectCartilage, Articular
dc.subjectCell Differentiation
dc.subjectCeramics
dc.subjectChondrocytes
dc.subjectHumans
dc.subjectModels, Animal
dc.subjectProstheses and Implants
dc.subjectStem Cells
dc.subjectTissue Engineering
dc.subjectTissue Scaffolds
dc.titleOsteochondral tissue engineering: scaffolds, stem cells and applications.
dc.typejournal-article
dc.typeJOUR
plymouth.author-urlhttp://www.ncbi.nlm.nih.gov/pubmed/22452848
plymouth.issue10
plymouth.volume16
plymouth.publication-statusPublished
plymouth.journalJ Cell Mol Med
dc.identifier.doi10.1111/j.1582-4934.2012.01571.x
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Dental School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeEngland
dc.identifier.eissn1582-4934
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1111/j.1582-4934.2012.01571.x
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record


All items in PEARL are protected by copyright law.
Author manuscripts deposited to comply with open access mandates are made available in accordance with publisher policies. Please cite only the published version using the details provided on the item record or document. In the absence of an open licence (e.g. Creative Commons), permissions for further reuse of content should be sought from the publisher or author.
Theme by 
Atmire NV