Osteochondral tissue engineering: scaffolds, stem cells and applications.
dc.contributor.author | Nooeaid, P | |
dc.contributor.author | Hagen, Chris | |
dc.contributor.author | Beier, JP | |
dc.contributor.author | Boccaccini, AR | |
dc.date.accessioned | 2018-08-13T14:36:47Z | |
dc.date.available | 2018-08-13T14:36:47Z | |
dc.date.issued | 2012-10 | |
dc.identifier.issn | 1582-4934 | |
dc.identifier.issn | 1582-4934 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/12103 | |
dc.description.abstract |
Osteochondral tissue engineering has shown an increasing development to provide suitable strategies for the regeneration of damaged cartilage and underlying subchondral bone tissue. For reasons of the limitation in the capacity of articular cartilage to self-repair, it is essential to develop approaches based on suitable scaffolds made of appropriate engineered biomaterials. The combination of biodegradable polymers and bioactive ceramics in a variety of composite structures is promising in this area, whereby the fabrication methods, associated cells and signalling factors determine the success of the strategies. The objective of this review is to present and discuss approaches being proposed in osteochondral tissue engineering, which are focused on the application of various materials forming bilayered composite scaffolds, including polymers and ceramics, discussing the variety of scaffold designs and fabrication methods being developed. Additionally, cell sources and biological protein incorporation methods are discussed, addressing their interaction with scaffolds and highlighting the potential for creating a new generation of bilayered composite scaffolds that can mimic the native interfacial tissue properties, and are able to adapt to the biological environment. | |
dc.format.extent | 2247-2270 | |
dc.format.medium | ||
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Wiley | |
dc.subject | Animals | |
dc.subject | Biocompatible Materials | |
dc.subject | Bone Regeneration | |
dc.subject | Bone and Bones | |
dc.subject | Cartilage, Articular | |
dc.subject | Cell Differentiation | |
dc.subject | Ceramics | |
dc.subject | Chondrocytes | |
dc.subject | Humans | |
dc.subject | Models, Animal | |
dc.subject | Prostheses and Implants | |
dc.subject | Stem Cells | |
dc.subject | Tissue Engineering | |
dc.subject | Tissue Scaffolds | |
dc.title | Osteochondral tissue engineering: scaffolds, stem cells and applications. | |
dc.type | journal-article | |
dc.type | JOUR | |
plymouth.author-url | http://www.ncbi.nlm.nih.gov/pubmed/22452848 | |
plymouth.issue | 10 | |
plymouth.volume | 16 | |
plymouth.publication-status | Published | |
plymouth.journal | J Cell Mol Med | |
dc.identifier.doi | 10.1111/j.1582-4934.2012.01571.x | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Dental School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | England | |
dc.identifier.eissn | 1582-4934 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1111/j.1582-4934.2012.01571.x | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.type | Journal Article/Review |