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dc.contributor.authorCreanor, Sen
dc.contributor.authorBarton, Aen
dc.contributor.authorMarchbank, Aen
dc.date.accessioned2018-08-13T14:21:36Z
dc.date.available2018-08-13T14:21:36Z
dc.date.issued2012-05en
dc.identifier.urihttp://hdl.handle.net/10026.1/12095
dc.description.abstract

INTRODUCTION: Gentamicin impregnated collagen sponges are licensed for use after cardiac surgery in over 50 countries but their effectiveness at preventing sternal wound infections (SWIs) remains uncertain. The aim of this meta-analysis was to assess the current evidence for effectiveness of such sponges at preventing SWIs in patients after cardiac surgery. METHODS: A systematic search of the literature was undertaken and meta-analyses were performed on the results of the identified, eligible studies. Using random effects models, odds ratios (OR) and corresponding 95% confidence intervals (CI) were calculated for all SWIs and deep SWIs for: a) all participants, and b) participants deemed as high risk. RESULTS: Three unique randomised controlled trials (published between 2005 and 2010) involving 3,994 participants met the inclusion criteria. There was insufficient evidence of a significant difference between intervention and control groups for all SWIs (all participants: OR: 0.66, 95% CI: 0.39-1.14; high risk participants: OR: 0.60, 95% CI: 0.24-1.52). There was insufficient evidence of a significant benefit of the sponge in deep SWIs across all participants (OR: 0.72, 95% CI: 0.47-1.10) but some evidence of benefit in terms of reducing the incidence of deep SWIs in high risk participants (OR: 0.62, 95% CI: 0.39-0.98). CONCLUSIONS: There is insufficient evidence of the effectiveness (or otherwise) of gentamicin impregnated sponges in preventing SWIs following cardiac surgery. However, some evidence does exist that such sponges can reduce the incidence of deep infections in high risk patients.

en
dc.format.extent227 - 231en
dc.languageengen
dc.language.isoengen
dc.subjectAnti-Bacterial Agentsen
dc.subjectCardiac Surgical Proceduresen
dc.subjectCollagenen
dc.subjectGentamicinsen
dc.subjectHumansen
dc.subjectRandomized Controlled Trials as Topicen
dc.subjectRisk Factorsen
dc.subjectSternumen
dc.subjectSurgical Spongesen
dc.subjectSurgical Wound Infectionen
dc.subjectTreatment Outcomeen
dc.titleEffectiveness of a gentamicin impregnated collagen sponge on reducing sternal wound infections following cardiac surgery: a meta-analysis of randomised controlled trials.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/22613298en
plymouth.issue4en
plymouth.volume94en
plymouth.publication-statusPublisheden
plymouth.journalAnn R Coll Surg Englen
dc.identifier.doi10.1308/003588412X13171221590179en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Health and Community
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBBB
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CCT&PS
dc.publisher.placeEnglanden
dc.identifier.eissn1478-7083en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1308/003588412X13171221590179en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.typeJournal Article/Reviewen


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