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dc.contributor.authorRodrigues, Sen
dc.contributor.authorDesroches, Men
dc.contributor.authorKrupa, Men
dc.contributor.authorCortes, Jen
dc.contributor.authorAfia, Aen

Asynchronous and spontaneous neurotransmitter release remain elusive and constitute topics of considerable research both from the experimental and modeling perspective. This study proposes a parsimonious model that accounts for all modes of vesicle exocytosis and Short-Term Synaptic Plasticity (STSP). The modeling novelty is based on principles of slow-fast dynamical systems theory. The model's validity is shown by its good agreement with experimental data obtained from in vitro electrophysiological dual whole-cell recordings between local cholecystokinin (CKK)-positive, Schaffer collateral associated (SCA) interneurons in the CA1 region of rat hippocampus~\cite{AfiaAli2007,AfiaAli2010}. These unitary synapses display asynchronous release, governed by the retrograde release of endocannabinoid in response to post-synaptic membrane depolarisation. This work will advance our understanding of the physiology underlying differential exocytosis, and facilitate large-scale neuronal simulations.

dc.titleModel for (a)synchronous/spontaneous release, applied to CCK-positive Interneuron synapsesen
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Engineering, Computing and Mathematics
dc.rights.embargoperiodNot knownen
rioxxterms.typeTechnical Reporten

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