Dietary lipid content reorganizes gut microbiota and probiotic L. rhamnosus attenuates obesity and enhances catabolic hormonal milieu in zebrafish
dc.contributor.author | Falcinelli, S | |
dc.contributor.author | Rodiles, A | |
dc.contributor.author | Hatef, A | |
dc.contributor.author | Picchietti, S | |
dc.contributor.author | Cossignani, L | |
dc.contributor.author | Merrifield, Daniel | |
dc.contributor.author | Unniappan, S | |
dc.contributor.author | Carnevali, O | |
dc.date.accessioned | 2018-07-30T10:13:49Z | |
dc.date.available | 2018-07-30T10:13:49Z | |
dc.date.issued | 2017-07-17 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.other | 5512 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/11948 | |
dc.description.abstract |
<jats:title>Abstract</jats:title><jats:p>In the present study, we explored whether dietary lipid content influences the gut microbiome in adult zebrafish. Diets containing three different lipid levels (high [HFD], medium [MFD], and low [LFD]) were administered with or without the supplementation of <jats:italic>Lactobacillus rhamnosus</jats:italic> (P) to zebrafish in order to explore how the dietary lipid content may influence the gut microbiome. Dietary lipid content shifted the gut microbiome structure. The addition of <jats:italic>L</jats:italic>. <jats:italic>rhamnosus</jats:italic> in the diets, induced transcriptional reduction of orexigenic genes, upregulation of anorexigenic genes, and transcriptional decrease of genes involved in cholesterol and triglyceride (TAG) metabolism, concomitantly with lower content of cholesterol and TAG. Probiotic feeding also decreased nesfatin-1 peptide in HFD-P and attenuated weight gain in HFD-P and MFD-P fed zebrafish, but not in LFD-P group. Intestinal ultrastructure was not affected by dietary fat level or probiotic inclusion. In conclusion, these findings underline the role of fat content in the diet in altering gut microbiota community by shifting phylotype composition and highlight the potential of probiotics to attenuate high-fat diet-related metabolic disorder.</jats:p> | |
dc.format.extent | 5512- | |
dc.format.medium | Electronic | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Nature Publishing Group | |
dc.subject | Animals | |
dc.subject | Appetite | |
dc.subject | Calcium-Binding Proteins | |
dc.subject | Cholesterol | |
dc.subject | DNA-Binding Proteins | |
dc.subject | Diet, High-Fat | |
dc.subject | Dietary Fats | |
dc.subject | Female | |
dc.subject | Gastrointestinal Microbiome | |
dc.subject | Intestines | |
dc.subject | Lacticaseibacillus rhamnosus | |
dc.subject | Lipid Droplets | |
dc.subject | Male | |
dc.subject | Nerve Tissue Proteins | |
dc.subject | Nucleobindins | |
dc.subject | Obesity | |
dc.subject | Principal Component Analysis | |
dc.subject | Probiotics | |
dc.subject | Triglycerides | |
dc.subject | Zebrafish | |
dc.subject | Zebrafish Proteins | |
dc.title | Dietary lipid content reorganizes gut microbiota and probiotic L. rhamnosus attenuates obesity and enhances catabolic hormonal milieu in zebrafish | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Research Support, Non-U.S. Gov't | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000405669600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 1 | |
plymouth.volume | 7 | |
plymouth.publication-status | Published online | |
plymouth.journal | Scientific Reports | |
dc.identifier.doi | 10.1038/s41598-017-05147-w | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Science and Engineering | |
plymouth.organisational-group | /Plymouth/Faculty of Science and Engineering/School of Biological and Marine Sciences | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA06 Agriculture, Veterinary and Food Science | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dc.publisher.place | England | |
dcterms.dateAccepted | 2017-05-24 | |
dc.identifier.eissn | 2045-2322 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1038/s41598-017-05147-w | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2017-07-17 | |
rioxxterms.type | Journal Article/Review |