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dc.contributor.authorSabour, D
dc.contributor.authorMachado, RSR
dc.contributor.authorPinto, JP
dc.contributor.authorRohani, S
dc.contributor.authorSahito, RGA
dc.contributor.authorHescheler, J
dc.contributor.authorFutschik, Matthias
dc.contributor.authorSachinidis, A
dc.date.accessioned2018-07-20T03:48:25Z
dc.date.available2018-07-20T03:48:25Z
dc.date.issued2018-09
dc.identifier.issn2162-2531
dc.identifier.issn2162-2531
dc.identifier.otherC
dc.identifier.urihttp://hdl.handle.net/10026.1/11859
dc.descriptionpublisher: Elsevier articletitle: Parallel Genome-wide Profiling of Coding and Non-coding RNAs to Identify Novel Regulatory Elements in Embryonic and Maturated Heart journaltitle: Molecular Therapy - Nucleic Acids articlelink: http://dx.doi.org/10.1016/j.omtn.2018.04.018 content_type: article copyright: © 2018 The Author(s).
dc.description.abstract

Heart development is a complex process, tightly regulated by numerous molecular mechanisms. Key components of the regulatory network underlying heart development are transcription factors (TFs) and microRNAs (miRNAs), yet limited investigation of the role of miRNAs in heart development has taken place. Here, we report the first parallel genome-wide profiling of polyadenylated RNAs and miRNAs in a developing murine heart. These data enable us to identify dynamic activation or repression of numerous biological processes and signaling pathways. More than 200 miRNAs and 25 long non-coding RNAs were differentially expressed during embryonic heart development compared to the mature heart; most of these had not been previously associated with cardiogenesis. Integrative analysis of expression data and potential regulatory interactions suggested 28 miRNAs as novel regulators of embryonic heart development, representing a considerable expansion of the current repertoire of known cardiac miRNAs. To facilitate follow-up investigations, we constructed HeartMiR (http://heartmir.sysbiolab.eu), an open access database and interactive visualization tool for the study of gene regulation by miRNAs during heart development.

dc.format.extent158-173
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoen
dc.publisherElsevier BV
dc.subjectHeartMiR database
dc.subjectbioinformatics
dc.subjectgene ontologies
dc.subjectgenomics
dc.subjectheart development
dc.subjectmiRNA and gene expression
dc.subjectmicroarrays
dc.subjectsignal transduction pathways
dc.subjecttranscription factors
dc.subjecttranscriptomics
dc.titleParallel Genome-wide Profiling of Coding and Non-coding RNAs to Identify Novel Regulatory Elements in Embryonic and Maturated Heart
dc.typejournal-article
dc.typeJournal Article
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000443860200014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.volume12
plymouth.publication-statusPublished
plymouth.journalMolecular Therapy - Nucleic Acids
dc.identifier.doi10.1016/j.omtn.2018.04.018
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Users by role
dc.publisher.placeUnited States
dcterms.dateAccepted2018-04-30
dc.rights.embargodate2018-7-21
dc.identifier.eissn2162-2531
dc.rights.embargoperiodNo embargo
rioxxterms.versionofrecord10.1016/j.omtn.2018.04.018
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-09
rioxxterms.typeJournal Article/Review


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