Now showing items 1-5 of 5
Macrophage subset sensitivity to endotoxin tolerisation by Porphyromonas gingivalis.
Macrophages (MΦs) determine oral mucosal responses; mediating tolerance to commensal microbes and food whilst maintaining the capacity to activate immune defences to pathogens. MΦ responses are determined by both differentiation ...
Intracellular NAD+ levels are associated with LPS-induced TNF-α release in pro-inflammatory macrophages.
Metabolism and immune responses have been shown to be closely linked and as our understanding increases, so do the intricacies of the level of linkage. NAD(+) has previously been shown to regulate tumour necrosis factor-α ...
Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology.
Probiotics are beneficial microbes that confer a realistic health benefit on the host, which in combination with prebiotics, (indigestible dietary fibre/carbohydrate), also confer a health benefit on the host via products ...
Heat-killed probiotic bacteria differentially regulate colonic epithelial cell production of human β-defensin-2: dependence on inflammatory cytokines.
The inducible antimicrobial peptide human β-defensin-2 (hBD-2) stimulated by pro-inflammatory cytokines and bacterial products is essential to antipathogen responses of gut epithelial cells. Commensal and probiotic bacteria ...
Probiotic bacterial strains differentially modulate macrophage cytokine production in a strain-dependent and cell subset-specific manner.
Gut mucosal macrophages play a pivotal role in driving mucosal immune responses, resulting in either activation of inflammatory immune responses to pathogenic challenge or tolerance to beneficial luminal contents such as ...