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Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer.

Jubb, AM; Soilleux, EJ; Turley, H; Steers, G; Parker, A; Low, I; Blades, J; Li, J-L; Allen, P; Leek, R; Noguera-Troise, I; Gatter, KC; Thurston, G; Harris, AL (2010-04)

Delta-like ligand 4 (Dll4) is a Notch ligand that is predominantly expressed in the endothelium. Evidence from xenografts suggests that inhibiting Dll4 may overcome resistance to antivascular endothelial growth factor ...

Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer.

Jubb, AM; Turley, H; Moeller, HC; Steers, G; Han, C; Li, J-L; Leek, R; Tan, EY; Singh, B; Mortensen, NJ; Noguera-Troise, I; Pezzella, F; Gatter, KC; Thurston, G; Fox, SB; Harris, AL (2009-11-17)

BACKGROUND: Delta-like ligand 4 (Dll4) is a Notch ligand that is upregulated by hypoxia and vascular endothelial growth factor-A (VEGF-A) and is reported to have a role in tumor angiogenesis. Evidence from xenograft studies ...