Browsing University of Plymouth Research Outputs by Issue Date
Now showing items 41-60 of 1944
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Identification of a second proliferating cell nuclear antigen in the human malarial pathogen Plasmodium falciparum.
(England, 2002-12-19)Proliferating cell nuclear antigen seems to exist as a single form in higher eukaryotic cells and plays multiple roles in nucleic acid metabolism. We have identified a second additional proliferating cell nuclear antigen ... -
Synthesis of Acetoxy Stabilised Indolequinones as Precursors to Model Eumelanin Polymers
(Georg Thieme Verlag KG, 2003) -
Proapoptotic genes BAX and CD40L are predictors of survival in transitional cell carcinoma of the bladder.
(England, 2003-02-24)The purpose of the study was to investigate the effects of expression of a range of genes involved in apoptosis on outcome in bladder cancer. Immunohistochemistry was used to examine expression of BCL2, BAX, P53, CD40 and ... -
Characterisation of a sexual stage-specific gene encoding ORC1 homologue in the human malaria parasite Plasmodium falciparum.
(Netherlands, 2003-03)The origin recognition complex (ORC) is a multisubunit protein composed of six polypeptides that binds to replication origins and is essential for the initiation of chromosomal DNA replication. Using the Vectorette ... -
Complete analysis of the B-cell response to a protein antigen, from in vivo germinal centre formation to 3-D modelling of affinity maturation.
(England, 2003-03)Somatic hypermutation of immunoglobulin variable region genes occurs within germinal centres (GCs) and is the process responsible for affinity maturation of antibodies during an immune response. Previous studies have ... -
GPCALMA, a mammographic CAD in a GRID connection
(2003-04-07)Purpose of this work is the development of an automatic system which could be useful for radiologists in the investigation of breast cancer. A breast neoplasia is often marked by the presence of microcalcifications and ... -
Diagnostic performance of radiologists with and without different CAD systems for mammography
(2003-07-19)The purpose of this study is the evaluation of the variation of performance in terms of sensitivity and specificity of two radiologists with different experience in mammography, with and without the assistance of two ... -
GPCALMA: a Grid Approach to Mammographic Screening
(2003-07-31)The next generation of High Energy Physics experiments requires a GRID approach to a distributed computing system and the associated data management: the key concept is the "Virtual Organisation" (VO), a group of ... -
Fuzzy Coding of Genetic Algorithms
(2003-08-01) -
Canal wall down mastoidectomy: A long term commitment to the outpatients?
(England, 2003-09-04)BACKGROUND: Canal wall down and canal wall up mastoidectomy represent two surgical approaches to middle ear cleft pathology. Very few studies have examined the effects of these procedures both on the patients' well being ... -
Spatial variation of Anopheles-transmitted Wuchereria bancrofti and Plasmodium falciparum infection densities in Papua New Guinea.
(England, 2003-09-14)The spatial variation of Wuchereria bancrofti and Plasmodium falciparum infection densities was measured in a rural area of Papua New Guinea where they share anopheline vectors. The spatial correlation of W. bancrofti was ... -
Increased brain histamine H3 receptor expression during hibernation in golden-mantled ground squirrels.
(England, 2003-09-24)BACKGROUND: Hibernation is a state of extremely reduced physiological functions and a deep depression of CNS activity. We have previously shown that the histamine levels increase in the brain during hibernation, as does ... -
Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D).
(United States, 2003-11-28)Bloom's syndrome (BS) is a genetic disorder associated with short stature, fertility defects, and a predisposition to the development of cancer. BS cells are characterized by genomic instability; in particular, a high ... -
Drosophila nonmuscle myosin II promotes the asymmetric segregation of cell fate determinants by cortical exclusion rather than active transport.
(United States, 2003-12)Cell fate diversity can be achieved through the asymmetric segregation of cell fate determinants. In the Drosophila embryo, neuroblasts divide asymmetrically and in a stem cell fashion. The determinants Prospero and Numb ...
