Now showing items 1-9 of 9

  • Achieving valid patient-reported outcomes measurement: a lesson from fatigue in multiple sclerosis. 

    Hobart, J; Cano, S; Baron, R; Thompson, A; Schwid, S; Zajicek, J; Andrich, D (England, 2013-11)
    BACKGROUND: The increasing influence of patient-reported outcome (PRO) measurement instruments indicates their scrutiny has never been more crucial. Above all, PRO instruments should be valid: shown to assess what they ...
  • Analysis and validation of a Parkinson's disease register as a recruitment tool for clinical studies. 

    Carroll, C; Palmer, A; Cosby, C; Zajicek, J (England, 2012-06)
    Promotion of research is a key strategy of the National Health Service (NHS). Currently, many patients are not afforded the opportunity to participate in clinical studies. A register of research-interested patients has ...
  • CBD & D9-THC - the two faces of cannabis 

    Zeissler; Carroll, CB; Zajicek, J (2010-05-10)
    Cannabidiol (CBD) and D9-tetrahydrocannabinol (D9-THC) are phytocannabinoids produced by the plant Cannabis sativa which have both shown promising therapeutic value as anti-inflammatory and neuroprotective agents in a ...
  • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. 

    International Multiple Sclerosis Genetics Consortium; Wellcome Trust Case Control Consortium 2; Sawcer, S; Hellenthal, G; Pirinen, M; Spencer, CCA; Patsopoulos, NA; Moutsianas, L; Dilthey, A; Su, Z; Freeman, C; Hunt, SE; Edkins, S; Gray, E; Booth, DR; Potter, SC; Goris, A; Band, G; Oturai, AB; Strange, A; Saarela, J; Bellenguez, C; Fontaine, B; Gillman, M; Hemmer, B; Gwilliam, R; Zipp, F; Jayakumar, A; Martin, R; Leslie, S; Hawkins, S; Giannoulatou, E; D'alfonso, S; Blackburn, H; Martinelli Boneschi, F; Liddle, J; Harbo, HF; Perez, ML; Spurkland, A; Waller, MJ; Mycko, MP; Ricketts, M; Comabella, M; Hammond, N; Kockum, I; McCann, OT; Ban, M; Whittaker, P; Kemppinen, A; Weston, P; Hawkins, C; Widaa, S; Zajicek, J; Dronov, S; Robertson, N; Bumpstead, SJ; Barcellos, LF; Ravindrarajah, R; Abraham, R; Alfredsson, L; Ardlie, K; Aubin, C; Baker, A; Baker, K; Baranzini, SE; Bergamaschi, L; Bergamaschi, R; Bernstein, A; Berthele, A; Boggild, M; Bradfield, JP; Brassat, D; Broadley, SA; Buck, D; Butzkueven, H; Capra, R; Carroll, WM; Cavalla, P; Celius, EG; Cepok, S; Chiavacci, R; Clerget-Darpoux, F; Clysters, K; Comi, G; Cossburn, M; Cournu-Rebeix, I; Cox, MB; Cozen, W; Cree, BAC; Cross, AH; Cusi, D; Daly, MJ; Davis, E; de Bakker, PIW; Debouverie, M; D'hooghe, MB; Dixon, K; Dobosi, R; Dubois, B; Ellinghaus, D; Elovaara, I; Esposito, F; Fontenille, C; Foote, S; Franke, A; Galimberti, D; Ghezzi, A; Glessner, J; Gomez, R; Gout, O; Graham, C; Grant, SFA; Guerini, FR; Hakonarson, H; Hall, P; Hamsten, A; Hartung, H-P; Heard, RN; Heath, S; Hobart, J; Hoshi, M; Infante-Duarte, C; Ingram, G; Ingram, W; Islam, T; Jagodic, M; Kabesch, M; Kermode, AG; Kilpatrick, TJ; Kim, C; Klopp, N; Koivisto, K; Larsson, M; Lathrop, M; Lechner-Scott, JS; Leone, MA; Leppä, V; Liljedahl, U; Bomfim, IL; Lincoln, RR; Link, J; Liu, J; Lorentzen, AR; Lupoli, S; Macciardi, F; Mack, T; Marriott, M; Martinelli, V; Mason, D; McCauley, JL; Mentch, F; Mero, I-L; Mihalova, T; Montalban, X; Mottershead, J; Myhr, K-M; Naldi, P; Ollier, W; Page, A; Palotie, A; Pelletier, J; Piccio, L; Pickersgill, T; Piehl, F; Pobywajlo, S; Quach, HL; Ramsay, PP; Reunanen, M; Reynolds, R; Rioux, JD; Rodegher, M; Roesner, S; Rubio, JP; Rückert, I-M; Salvetti, M; Salvi, E; Santaniello, A; Schaefer, CA; Schreiber, S; Schulze, C; Scott, RJ; Sellebjerg, F; Selmaj, KW; Sexton, D; Shen, L; Simms-Acuna, B; Skidmore, S; Sleiman, PMA; Smestad, C; Sørensen, PS; Søndergaard, HB; Stankovich, J; Strange, RC; Sulonen, A-M; Sundqvist, E; Syvänen, A-C; Taddeo, F; Taylor, B; Blackwell, JM; Tienari, P; Bramon, E; Tourbah, A; Brown, MA; Tronczynska, E; Casas, JP; Tubridy, N; Corvin, A; Vickery, J; Jankowski, J; Villoslada, P; Markus, HS; Wang, K; Mathew, CG; Wason, J; Palmer, CNA; Wichmann, H-E; Plomin, R; Willoughby, E; Rautanen, A; Winkelmann, J; Wittig, M; Trembath, RC; Yaouanq, J; Viswanathan, AC; Zhang, H; Wood, NW; Zuvich, R; Deloukas, P; Langford, C; Duncanson, A; Oksenberg, JR; Pericak-Vance, MA; Haines, JL; Olsson, T; Hillert, J; Ivinson, AJ; De Jager, PL; Peltonen, L; Stewart, GJ; Hafler, DA; Hauser, SL; McVean, G; Donnelly, P; Compston, A (England, 2011-08-10)
    Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by ...
  • Machine-learning based identification of undiagnosed dementia in primary care: a feasibility study 

    Jammeh, EA; Carroll, CB; Pearson, SW; Escudero, J; Anastasiou, A; Zhao, P; Chenore, T; Zajicek, J; Ifeachor, E
  • Molecular genetic studies of neurodegenerative disease. 

    Cooke, T; Carroll, C; Zajicek, J; Ellard, S; Morrison, K (England, 2013-11)
    Large scale genetic studies such as genome-wide association studies (GWAS) in Parkinson's disease (PD) have revealed genetic susceptibility factors and continue to offer new insights both into the genetics of sporadic ...
  • Provision of 24 hour acute neurology care by neurologists: manpower requirements in the UK. 

    Carroll, C; Zajicek, J (England, 2004-03)
    OBJECTIVES: The ABN has published standards of care for patients with acute neurological disease. Derriford Hospital provides a 24 hour neurology intake service to a population of 500,000 with the equivalent of four ...
  • Quantifying drug-induced dyskinesias in the arms using digitised spiral-drawing tasks. 

    Liu, X; Carroll, CB; Wang, S-Y; Zajicek, J; Bain, PG (Netherlands, 2005-05-15)
    In this study, we quantify the severity of drug-induced dyskinesias in the arms of Parkinson's disease (PD) patients using digitised spiral-drawing tasks. Two spiral drawings, namely a circular and a square spiral, are ...
  • Δ9-TETRAHYDROCANNABINOL IS PROTECTIVE THROUGH PPARγ DEPENDENT MITOCHONDRIAL BIOGENESIS IN A CELL CULTURE MODEL OF PARKINSON'S DISEASE. 

    Zeissler, ML; Eastwood, J; Oliver Hanemann, C; Zajicek, J; Carroll, C (England, 2013-11)
    Cannabinoids such as Δ9-tetrahydrocannabinol (Δ9-THC) are neuroprotective in animal and cell culture models of Parkinson's disease (PD). In a PD cell culture model we recently demonstrated that Δ9-THC is neuroprotective ...

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