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  • A variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms. 

    Sharkawy, RE; Bayoumi, A; Metwally, M; Mangia, A; Berg, T; Romero-Gomez, M; Abate, ML; Irving, WL; Sheridan, D; Dore, GJ; Spengler, U; Lampertico, P; Bugianesi, E; Weltman, M; Mollison, L; Cheng, W; Riordan, S; Santoro, R; Gallego-Durán, R; Fischer, J; Nattermann, J; D'Ambrosio, R; McLeod, D; Powell, E; Latchoumanin, O; Thabet, K; Najim, MAM; Douglas, MW; Liddle, C; Qiao, L; George, J; Eslam, M; International Liver Disease Genetics Consortium (ILDGC) (Nature Research (part of Springer Nature), 2019-02-05)
    Hepatocarcinogenesis is tightly linked to liver fibrosis. Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma ...

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