Browsing University of Plymouth Research Outputs by Author "55028bbf-522a-4a53-b84d-bfaea675e5a6"
The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer da Motta, LL; Ledaki, I; Purshouse, K; Haider, S; De Bastiani, MA; Baban, D; Morotti, M; Steers, G; Wigfield, S; Bridges, E; Li, J-L; Knapp, S; Ebner, D; Klamt, F; Harris, AL; McIntyre, A (2016-06-13)
Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition. Ledaki, I; McIntyre, A; Wigfield, S; Buffa, F; McGowan, S; Baban, D; Li, J-L; Harris, AL (United States, 2015-08-14)Carbonic anhydrase IX (CAIX) is strongly induced by hypoxia and its overexpression is associated with poor therapeutic outcome in cancer. Here, we report that hypoxia promotes tumour heterogeneity through the epigenetic ...