Browsing University of Plymouth Research Outputs by Author "21263b72-9493-4c8c-abfe-4bcad3450e9f"

Now showing items 1-4 of 4

  • Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes 

    Eslam, M; Mangia, A; Berg, T; Chan, HLY; Irving, WL; Dore, GJ; Abate, ML; Bugianesi, E; Adams, LA; Najim, MAM; Miele, L; Weltman, M; Mollison, L; Cheng, W; Riordan, S; Fischer, J; Romero-Gomez, M; Spengler, U; Nattermann, J; Rahme, A; Sheridan, D; Booth, DR; McLeod, D; Powell, E; Liddle, C; Douglas, MW; van der Poorten, D; George, J (2016-06-22)

  • IFN-λ3, not IFN-λ4, likely mediates IFNL3–IFNL4 haplotype–dependent hepatic inflammation and fibrosis 

    Eslam, M; McLeod, D; Kelaeng, KS; Mangia, A; Berg, T; Thabet, K; Irving, WL; Dore, GJ; Sheridan, D; Grønbæk, H; Abate, ML; Hartmann, R; Bugianesi, E; Spengler, U; Rojas, A; Booth, DR; Weltman, M; Mollison, L; Cheng, W; Riordan, S; Mahajan, H; Fischer, J; Nattermann, J; Douglas, MW; Liddle, C; Powell, E; Romero-Gomez, M; George, J; Metwally, M; White, R; Gallego-Duran, R; Leung, R; Mahajan, N; Bassendine, M; Rahme, A; Rosso, C; Mezzabotta, L; Malik, B; Matthews, G; Asimakopoulos, A; Applegate, T; Grebely, J; Fragomeli, V; Jonsson, JR; Santoro, R (2017-04-10)

  • Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease. 

    Eslam, M; Hashem, AM; Leung, R; Romero-Gomez, M; Berg, T; Dore, GJ; Chan, HLK; Irving, WL; Sheridan, D; Abate, ML; Adams, LA; Mangia, A; Weltman, M; Bugianesi, E; Spengler, U; Shaker, O; Fischer, J; Mollison, L; Cheng, W; Powell, E; Nattermann, J; Riordan, S; McLeod, D; Armstrong, NJ; Douglas, MW; Liddle, C; Booth, DR; George, J; Ahlenstiel, G; International Hepatitis C Genetics Consortium (IHCGC) (England, 2015-03-05)
    Tissue fibrosis is a core pathologic process that contributes to mortality in ~45% of the population and is likely to be influenced by the host genetic architecture. Here we demonstrate, using liver disease as a model, ...

  • A variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms. 

    Sharkawy, RE; Bayoumi, A; Metwally, M; Mangia, A; Berg, T; Romero-Gomez, M; Abate, ML; Irving, WL; Sheridan, D; Dore, GJ; Spengler, U; Lampertico, P; Bugianesi, E; Weltman, M; Mollison, L; Cheng, W; Riordan, S; Santoro, R; Gallego-Durán, R; Fischer, J; Nattermann, J; D'Ambrosio, R; McLeod, D; Powell, E; Latchoumanin, O; Thabet, K; Najim, MAM; Douglas, MW; Liddle, C; Qiao, L; George, J; Eslam, M; International Liver Disease Genetics Consortium (ILDGC) (Nature Research (part of Springer Nature), 2019-02-05)
    Hepatocarcinogenesis is tightly linked to liver fibrosis. Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma ...
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