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Pathophysiology of chronic subdural haematoma: inflammation, angiogenesis and implications for pharmacotherapy.

Edlmann, E; Giorgi-Coll, S; Whitfield, PC; Carpenter, KLH; Hutchinson, PJ (2017-05-30)

Chronic subdural haematoma (CSDH) is an encapsulated collection of blood and fluid on the surface of the brain. Historically considered a result of head trauma, recent evidence suggests there are more complex processes ...

Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial: study protocol for a randomised controlled trial.

Kolias, AG; Edlmann, E; Thelin, EP; Bulters, D; Holton, P; Suttner, N; Owusu-Agyemang, K; Al-Tamimi, YZ; Gatt, D; Thomson, S; Anderson, IA; Richards, O; Whitfield, P; Gherle, M; Caldwell, K; Davis-Wilkie, C; Tarantino, S; Barton, G; Marcus, HJ; Chari, A; Brennan, P; Belli, A; Bond, S; Turner, C; Whitehead, L; Wilkinson, I; Hutchinson, PJ; British Neurosurgical Trainee Research Collaborative (BNTRC) and Dex-CSDH Trial Collaborators (2018-12-04)

BACKGROUND: Chronic subdural haematoma (CSDH) is a common neurosurgical condition, typically treated with surgical drainage of the haematoma. However, surgery is associated with mortality and morbidity, including up to 20% ...

Outcomes following surgery in subgroups of comatose and very elderly patients with chronic subdural hematoma.

Christopher, E; Poon, MTC; Glancz, LJ; Hutchinson, PJ; Kolias, AG; Brennan, PM; British Neurosurgical Trainee Research Collaborative (BNTRC) (2019-06)

Increasing age and lower pre-operative Glasgow coma score (GCS) are associated with worse outcome after surgery for chronic subdural haematoma (CSDH). Only few studies have quantified outcomes specific to the very elderly ...

Dex-CSDH randomised, placebo-controlled trial of dexamethasone for chronic subdural haematoma: report of the internal pilot phase.

Edlmann, E; Thelin, EP; Caldwell, K; Turner, C; Whitfield, P; Bulters, D; Holton, P; Suttner, N; Owusu-Agyemang, K; Al-Tamimi, YZ; Gatt, D; Thomson, S; Anderson, IA; Richards, O; Gherle, M; Toman, E; Nandi, D; Kane, P; Pantaleo, B; Davis-Wilkie, C; Tarantino, S; Barton, G; Marcus, HJ; Chari, A; Belli, A; Bond, S; Gafoor, R; Dawson, S; Whitehead, L; Brennan, P; Wilkinson, I; Kolias, AG; Hutchinson, PJA; Dex-CSDH trial collaborative and BNTRC collaborative. (2019-04-10)

The Dex-CSDH trial is a randomised, double-blind, placebo-controlled trial of dexamethasone for patients with a symptomatic chronic subdural haematoma. The trial commenced with an internal pilot, whose primary objective ...