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dc.contributor.authorFouragnan, E
dc.contributor.authorRetzler, C
dc.contributor.authorMullinger, K
dc.contributor.authorPhiliastides, MG
dc.date.accessioned2018-05-15T14:32:46Z
dc.date.available2018-05-15T14:32:46Z
dc.date.issued2015-11
dc.identifier.issn2041-1723
dc.identifier.issn2041-1723
dc.identifier.other8107
dc.identifier.urihttp://hdl.handle.net/10026.1/11508
dc.description.abstract

<jats:title>Abstract</jats:title><jats:p>Avoiding repeated mistakes and learning to reinforce rewarding decisions is critical for human survival and adaptive actions. Yet, the neural underpinnings of the value systems that encode different decision-outcomes remain elusive. Here coupling single-trial electroencephalography with simultaneously acquired functional magnetic resonance imaging, we uncover the spatiotemporal dynamics of two separate but interacting value systems encoding decision-outcomes. Consistent with a role in regulating alertness and switching behaviours, an early system is activated only by negative outcomes and engages arousal-related and motor-preparatory brain structures. Consistent with a role in reward-based learning, a later system differentially suppresses or activates regions of the human reward network in response to negative and positive outcomes, respectively. Following negative outcomes, the early system interacts and downregulates the late system, through a thalamic interaction with the ventral striatum. Critically, the strength of this coupling predicts participants’ switching behaviour and avoidance learning, directly implicating the thalamostriatal pathway in reward-based learning.</jats:p>

dc.format.extent0-0
dc.format.mediumElectronic
dc.languageen
dc.language.isoen
dc.publisherSpringer Science and Business Media LLC
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAvoidance Learning
dc.subjectBrain
dc.subjectBrain Mapping
dc.subjectDecision Making
dc.subjectElectroencephalography
dc.subjectFemale
dc.subjectFunctional Neuroimaging
dc.subjectHumans
dc.subjectImage Processing, Computer-Assisted
dc.subjectLearning
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectNeural Pathways
dc.subjectNucleus Accumbens
dc.subjectReward
dc.subjectThalamus
dc.subjectYoung Adult
dc.titleTwo spatiotemporally distinct value systems shape reward-based learning in the human brain
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/26348160
plymouth.issue0
plymouth.volume6
plymouth.publisher-urlhttp://dx.doi.org/10.1038/ncomms9107
plymouth.publication-statusPublished online
plymouth.journalNature Communications
dc.identifier.doi10.1038/ncomms9107
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Psychology
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA04 Psychology, Psychiatry and Neuroscience
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
plymouth.organisational-group/Plymouth/Users by role/Researchers in ResearchFish submission
dc.publisher.placeEngland
dcterms.dateAccepted2015-07-20
dc.identifier.eissn2041-1723
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1038/ncomms9107
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2015-11
rioxxterms.typeJournal Article/Review


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