Show simple item record

dc.contributor.authorRudolf, R
dc.contributor.authorBusch, R
dc.contributor.authorPatra, AK
dc.contributor.authorMuhammad, K
dc.contributor.authorAvots, A
dc.contributor.authorAndrau, J-C
dc.contributor.authorKlein-Hessling, S
dc.contributor.authorSerfling, E
dc.date.accessioned2018-05-14T13:09:19Z
dc.date.issued2014-02-03
dc.identifier.issn1664-3224
dc.identifier.issn1664-3224
dc.identifier.otherARTN 21
dc.identifier.urihttp://hdl.handle.net/10026.1/11502
dc.description.abstract

In lymphocytes, the three NFAT factors NFATc1 (also designated as NFAT2), NFATc2 (NFAT1), and NFATc3 (NFAT4 or NFATx) are expressed and are the targets of immune receptor signals, which lead to a rapid rise of intracellular Ca(++), the activation of phosphatase calcineurin, and to the activation of cytosolic NFATc proteins. In addition to rapid activation of NFAT factors, immune receptor signals lead to accumulation of the short NFATc1/αA isoform in lymphocytes which controls their proliferation and survival. In this mini-review, we summarize our current knowledge on the structure and transcription of the Nfatc1 gene in lymphocytes, which is controlled by two promoters, two poly A addition sites and a remote downstream enhancer. The Nfatc1 gene resembles numerous primary response genes (PRGs) induced by LPS in macrophages. Similar to the PRG promoters, the Nfatc1 promoter region is organized in CpG islands, forms DNase I hypersensitive sites, and is marked by histone tail modifications before induction. By studying gene induction in lymphocytes in detail, it will be important to elucidate whether the properties of the Nfatc1 induction are not only typical for the Nfatc1 gene but also for other transcription factor genes expressed in lymphocytes.

dc.format.extent21-
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.language.isoeng
dc.publisherFrontiers Media SA
dc.subjectchromatin
dc.subjectinduction
dc.subjectlymphocytes
dc.subjectNfatc1
dc.subjecttranscription
dc.titleArchitecture and Expression of the Nfatc1 Gene in Lymphocytes
dc.typejournal-article
dc.typeJournal Article
dc.typeReview
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000354457100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issueFEB
plymouth.volume5
plymouth.publication-statusPublished online
plymouth.journalFrontiers in Immunology
dc.identifier.doi10.3389/fimmu.2014.00021
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeSwitzerland
dcterms.dateAccepted2014-01-15
dc.identifier.eissn1664-3224
dc.rights.embargoperiodNo embargo
rioxxterms.versionofrecord10.3389/fimmu.2014.00021
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2014
rioxxterms.typeJournal Article/Review


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record


All items in PEARL are protected by copyright law.
Author manuscripts deposited to comply with open access mandates are made available in accordance with publisher policies. Please cite only the published version using the details provided on the item record or document. In the absence of an open licence (e.g. Creative Commons), permissions for further reuse of content should be sought from the publisher or author.
Theme by 
Atmire NV