Endoscopic Resection and Topical 5-Fluorouracil as an Alternative Treatment to Craniofacial Resection for the Management of Primary Intestinal-Type Sinonasal Adenocarcinoma
dc.contributor.author | Mackie, S | |
dc.contributor.author | Malik, T | |
dc.contributor.author | Khalil, Hisham | |
dc.date.accessioned | 2018-04-23T03:09:51Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 2090-1445 | |
dc.identifier.issn | 2090-1453 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/11317 | |
dc.description.abstract |
<jats:p><jats:italic>Introduction</jats:italic>. Intestinal-type adenocarcinoma of the sinonasal tract is very rare and is responsible for less than 4% of tumours of the sinuses. Craniofacial resection has been the mainstay of treatment for many years; however, techniques for endoscopic resection are constantly being developed.<jats:italic>Discussion</jats:italic>. The use of transnasal endoscopic resection (TER) and topical chemotherapy applications as an alternative to cranio-facial resection (CFR) is discussed. TER offers advantages over CFR in terms of fewer intra-operative complications and an improved cosmetic outcome. Survival and metastatic rates are similar between both procedures. Patients with locally invasive tumours are better managed with CFR. Topical applications of 5-Fluorouracil has been shown to be effective in increasing survival in patients with sino-nasal malignancy.<jats:italic>Conclusion</jats:italic>. Trans-nasal endoscopic resection and topical 5-Fluorouracil could potentially offer an acceptable alternative treatment to the standard of cranio-facial resection. This should be investigated in trials with a longer followup period than this paper in order to directly compare the two treatment modalities.</jats:p> | |
dc.format.extent | 1-4 | |
dc.format.medium | Print-Electronic | |
dc.language | en | |
dc.language.iso | eng | |
dc.publisher | Hindawi Limited | |
dc.subject | Dental/Oral and Craniofacial Disease | |
dc.subject | Rare Diseases | |
dc.subject | Cancer | |
dc.title | Endoscopic Resection and Topical 5-Fluorouracil as an Alternative Treatment to Craniofacial Resection for the Management of Primary Intestinal-Type Sinonasal Adenocarcinoma | |
dc.type | journal-article | |
dc.type | Case Reports | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/22091355 | |
plymouth.volume | 2010 | |
plymouth.publication-status | Published | |
plymouth.journal | Minimally Invasive Surgery | |
dc.identifier.doi | 10.1155/2010/750253 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Medical School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2010-12-28 | |
dc.identifier.eissn | 2090-1453 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1155/2010/750253 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2010 | |
rioxxterms.type | Journal Article/Review |