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dc.contributor.authorLi, W-C
dc.contributor.authorMerrison-Hort, R
dc.contributor.authorZhang, H-Y
dc.contributor.authorBorisyuk, R
dc.date.accessioned2018-03-27T10:31:38Z
dc.date.available2018-03-27T10:31:38Z
dc.date.issued2014-04-23
dc.identifier.issn0270-6474
dc.identifier.issn1529-2401
dc.identifier.urihttp://hdl.handle.net/10026.1/11182
dc.description.abstract

<jats:p>Many neural circuits are capable of generating multiple stereotyped outputs after different sensory inputs or neuromodulation. We have previously identified the central pattern generator (CPG) for<jats:italic>Xenopus</jats:italic>tadpole swimming that involves antiphase oscillations of activity between the left and right sides. Here we analyze the cellular basis for spontaneous left–right motor synchrony characterized by simultaneous bursting on both sides at twice the swimming frequency. Spontaneous synchrony bouts are rare in most tadpoles, and they instantly emerge from and switch back to swimming, most frequently within the first second after skin stimulation. Analyses show that only neurons that are active during swimming fire action potentials in synchrony, suggesting both output patterns derive from the same neural circuit. The firing of excitatory descending interneurons (dINs) leads that of other types of neurons in synchrony as it does in swimming. During synchrony, the time window between phasic excitation and inhibition is 7.9 ± 1 ms, shorter than that in swimming (41 ± 2.3 ms). The occasional, extra midcycle firing of dINs during swimming may initiate synchrony, and mismatches of timing in the left and right activity can switch synchrony back to swimming. Computer modeling supports these findings by showing that the same neural network, in which reciprocal inhibition mediates rebound firing, can generate both swimming and synchrony without circuit reconfiguration. Modeling also shows that lengthening the time window between phasic excitation and inhibition by increasing dIN synaptic/conduction delay can improve the stability of synchrony.</jats:p>

dc.format.extent6065-6077
dc.format.mediumPrint
dc.languageen
dc.language.isoeng
dc.publisherSociety for Neuroscience
dc.subjectcentral pattern generator
dc.subjectlocomotion
dc.subjectoscillations
dc.subjectspinal cord
dc.subjectswimming
dc.subjectsynchrony
dc.titleThe Generation of Antiphase Oscillations and Synchrony by a Rebound-Based Vertebrate Central Pattern Generator
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/24760866
plymouth.issue17
plymouth.volume34
plymouth.publisher-urlhttp://dx.doi.org/10.1523/jneurosci.4198-13.2014
plymouth.publication-statusPublished
plymouth.journalThe Journal of Neuroscience
dc.identifier.doi10.1523/jneurosci.4198-13.2014
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA11 Computer Science and Informatics
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Researchers in ResearchFish submission
dc.publisher.placeUnited States
dc.identifier.eissn1529-2401
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1523/jneurosci.4198-13.2014
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
plymouth.funderCross-modality integration of sensory signals leading to initiation of locomotion::BBSRC
plymouth.funderCross-modality integration of sensory signals leading to initiation of locomotion::BBSRC
plymouth.oa-locationhttp://www.jneurosci.org/content/34/17/6065.full.pdf+html


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