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dc.contributor.authorLi, W-Cen
dc.contributor.authorMerrison-Hort, Ren
dc.contributor.authorZhang, H-Yen
dc.contributor.authorBorisyuk, Ren
dc.date.accessioned2018-03-27T10:31:38Z
dc.date.available2018-03-27T10:31:38Z
dc.date.issued2014-04-23en
dc.identifier.urihttp://hdl.handle.net/10026.1/11182
dc.description.abstract

Many neural circuits are capable of generating multiple stereotyped outputs after different sensory inputs or neuromodulation. We have previously identified the central pattern generator (CPG) for Xenopus tadpole swimming that involves antiphase oscillations of activity between the left and right sides. Here we analyze the cellular basis for spontaneous left-right motor synchrony characterized by simultaneous bursting on both sides at twice the swimming frequency. Spontaneous synchrony bouts are rare in most tadpoles, and they instantly emerge from and switch back to swimming, most frequently within the first second after skin stimulation. Analyses show that only neurons that are active during swimming fire action potentials in synchrony, suggesting both output patterns derive from the same neural circuit. The firing of excitatory descending interneurons (dINs) leads that of other types of neurons in synchrony as it does in swimming. During synchrony, the time window between phasic excitation and inhibition is 7.9 ± 1 ms, shorter than that in swimming (41 ± 2.3 ms). The occasional, extra midcycle firing of dINs during swimming may initiate synchrony, and mismatches of timing in the left and right activity can switch synchrony back to swimming. Computer modeling supports these findings by showing that the same neural network, in which reciprocal inhibition mediates rebound firing, can generate both swimming and synchrony without circuit reconfiguration. Modeling also shows that lengthening the time window between phasic excitation and inhibition by increasing dIN synaptic/conduction delay can improve the stability of synchrony.

en
dc.format.extent6065 - 6077en
dc.languageengen
dc.language.isoengen
dc.subjectcentral pattern generatoren
dc.subjectlocomotionen
dc.subjectoscillationsen
dc.subjectspinal corden
dc.subjectswimmingen
dc.subjectsynchronyen
dc.subjectAction Potentialsen
dc.subjectAnimalsen
dc.subjectCentral Pattern Generatorsen
dc.subjectInterneuronsen
dc.subjectLocomotionen
dc.subjectModels, Neurologicalen
dc.subjectMotor Neuronsen
dc.subjectNeural Inhibitionen
dc.subjectNeuronsen
dc.subjectSpinal Corden
dc.subjectSwimmingen
dc.subjectXenopusen
dc.titleThe generation of antiphase oscillations and synchrony by a rebound-based vertebrate central pattern generator.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/24760866en
plymouth.issue17en
plymouth.volume34en
plymouth.publication-statusPublisheden
plymouth.journalJ Neuroscien
dc.identifier.doi10.1523/JNEUROSCI.4198-13.2014en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Engineering, Computing and Mathematics
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA11 Computer Science and Informatics
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Professional Services staff
dc.publisher.placeUnited Statesen
dc.identifier.eissn1529-2401en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1523/JNEUROSCI.4198-13.2014en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.typeJournal Article/Reviewen
plymouth.funderCross-modality integration of sensory signals leading to initiation of locomotion::BBSRCen
plymouth.oa-locationhttp://www.jneurosci.org/content/34/17/6065.full.pdf+htmlen


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