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dc.contributor.authorSakulkoo, W
dc.contributor.authorOsés-Ruiz, M
dc.contributor.authorOliveira Garcia, E
dc.contributor.authorSoanes, DM
dc.contributor.authorLittlejohn, George
dc.contributor.authorHacker, C
dc.contributor.authorCorreia, A
dc.contributor.authorValent, B
dc.contributor.authorTalbot, NJ
dc.date.accessioned2018-03-23T11:27:01Z
dc.date.available2018-03-23T11:27:01Z
dc.date.issued2018-03-23
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203
dc.identifier.other0
dc.identifier.urihttp://hdl.handle.net/10026.1/11165
dc.description.abstract

When the rice blast fungus enters a rice cell, the plasma membrane stays intact, so the rice cell remains viable. The fungus then moves to adjacent cells via plasmodesmata, the plant’s intercellular channels. Sakulkoo et al. used a chemical genetic approach to selectively inhibit a single MAP (mitogen-activated protein) kinase, Pmk1, in the blast fungus. Inhibition of Pmk1 trapped the fungus within a rice cell. Pmk1 regulated the expression of a suite of effector genes involved in suppression of host immunity, allowing the fungus to manipulate plasmodesmal conductance. At the same time, Pmk1 regulated the fungus’s hyphal constriction, which allows movement into new host cells.Science, this issue p. 1399Blast disease destroys up to 30% of the rice crop annually and threatens global food security. The blast fungus Magnaporthe oryzae invades plant tissue with hyphae that proliferate and grow from cell to cell, often through pit fields, where plasmodesmata cluster. We showed that chemical genetic inhibition of a single fungal mitogen-activated protein (MAP) kinase, Pmk1, prevents M. oryzae from infecting adjacent plant cells, leaving the fungus trapped within a single plant cell. Pmk1 regulates expression of secreted fungal effector proteins implicated in suppression of host immune defenses, preventing reactive oxygen species generation and excessive callose deposition at plasmodesmata. Furthermore, Pmk1 controls the hyphal constriction required for fungal growth from one rice cell to the neighboring cell, enabling host tissue colonization and blast disease.

dc.format.extent1399-1403
dc.format.mediumPrint
dc.languageen
dc.language.isoen
dc.publisherAmerican Association for the Advancement of Science
dc.subjectDisease Resistance
dc.subjectHost-Pathogen Interactions
dc.subjectHyphae
dc.subjectMagnaporthe
dc.subjectMitogen-Activated Protein Kinases
dc.subjectOryza
dc.subjectPlant Cells
dc.subjectPlant Diseases
dc.titleA single fungal MAP kinase controls plant cell-to-cell invasion by the rice blast fungus
dc.typejournal-article
dc.typearticle
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000428043600045&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue6382
plymouth.volume359
plymouth.publisher-urlhttp://science.sciencemag.org/content/359/6382/1399
plymouth.publication-statusPublished
plymouth.journalScience
dc.identifier.doi10.1126/science.aaq0892
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Biological and Marine Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA06 Agriculture, Veterinary and Food Science
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeUnited States
dcterms.dateAccepted2018-01-24
dc.identifier.eissn1095-9203
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1126/science.aaq0892
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-03-23
rioxxterms.typeJournal Article/Review


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