The formation of autophagosomes during lysosomal defect: A new source of cytotoxicity
dc.contributor.author | Button, RW | |
dc.contributor.author | Luo, Shouqing | |
dc.date.accessioned | 2018-03-20T09:25:27Z | |
dc.date.issued | 2017-08-18 | |
dc.identifier.issn | 1554-8627 | |
dc.identifier.issn | 1554-8635 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/11111 | |
dc.description | peerreview_statement: The publishing and review policy for this title is described in its Aims & Scope. aims_and_scope_url: http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=kaup20 | |
dc.description.abstract |
Macroautophagy/autophagy comprises autophagosome synthesis and lysosomal degradation. It is well known that lysosomal defects cause toxicity to cells. However, it has not been investigated previously if cytotoxicity is conferred by autophagosome formation during lysosomal defect. Recently, we found that the formation of autophagosomes in such conditions also causes cytotoxicity, in addition to lysosomal defect insults. We revealed that a partial reduction in autophagosome synthesis was beneficial for cell survival in cells bearing the autophagosome formation-based toxicity. Our study suggests that production/accumulation of autophagosomes during lysosomal defect directly induces cellular toxicity, and this process may be implicated in the pathological conditions where lysosomes are defective. | |
dc.format.extent | 1-2 | |
dc.format.medium | Print-Electronic | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Informa UK Limited | |
dc.subject | MTOR | |
dc.subject | STX17 | |
dc.subject | autophagosome | |
dc.subject | autophagy | |
dc.subject | cytotoxicity | |
dc.subject | Animals | |
dc.subject | Autophagosomes | |
dc.subject | Autophagy | |
dc.subject | Cell Death | |
dc.subject | Cell Survival | |
dc.subject | Gene Knockdown Techniques | |
dc.subject | Humans | |
dc.subject | Lysosomes | |
dc.subject | Organelle Biogenesis | |
dc.subject | Qa-SNARE Proteins | |
dc.subject | TOR Serine-Threonine Kinases | |
dc.title | The formation of autophagosomes during lysosomal defect: A new source of cytotoxicity | |
dc.type | journal-article | |
dc.type | Journal Article | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/28820297 | |
plymouth.issue | 10 | |
plymouth.volume | 13 | |
plymouth.publication-status | Published | |
plymouth.journal | Autophagy | |
dc.identifier.doi | 10.1080/15548627.2017.1358850 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Medical School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2017-07-18 | |
dc.rights.embargodate | 2018-8-18 | |
dc.identifier.eissn | 1554-8635 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1080/15548627.2017.1358850 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2017-08-18 | |
rioxxterms.type | Journal Article/Review | |
plymouth.funder | Tackling autophagy and apoptosis for the potential therapy of Huntington's Disease::MRC |