β-Adrenoceptor blockade modulates fusiform gyrus activity to black versus white faces.
dc.contributor.author | Terbeck, S | en |
dc.contributor.author | Kahane, G | en |
dc.contributor.author | McTavish, S | en |
dc.contributor.author | McCutcheon, R | en |
dc.contributor.author | Hewstone, M | en |
dc.contributor.author | Savulescu, J | en |
dc.contributor.author | Chesterman, LP | en |
dc.contributor.author | Cowen, PJ | en |
dc.contributor.author | Norbury, R | en |
dc.date.accessioned | 2018-02-14T14:10:12Z | |
dc.date.available | 2018-02-14T14:10:12Z | |
dc.date.issued | 2015-08 | en |
dc.identifier.uri | http://hdl.handle.net/10026.1/10776 | |
dc.description.abstract |
INTRODUCTION: The beta-adrenoceptor antagonist propranolol is known to reduce peripheral and central activity of noradrenaline. A recent study found that intervention with propranolol diminished negative implicit racial bias. MATERIALS AND METHOD: The current study used functional magnetic resonance imaging (fMRI) in order to determine the neural correlates of this effect. Healthy volunteers (N = 40) of white ethnic origin received a single oral dose (40 mg) of propranolol, in a randomised, double-blind, parallel group, placebo-controlled design, before viewing unfamiliar faces of same and other race. RESULTS AND DISCUSSION: We found significantly reduced activity in the fusiform gyrus and thalamus following propranolol to out-group faces only. Additionally, propranolol lowered the implicit attitude score, without affecting explicit prejudice measure. CONCLUSION: These findings suggest that noradrenaline pathways might modulate racial bias by acting on the processing of categorisation in the fusiform gyrus. | en |
dc.format.extent | 2951 - 2958 | en |
dc.language | eng | en |
dc.language.iso | eng | en |
dc.subject | Adrenergic beta-Antagonists | en |
dc.subject | African Americans | en |
dc.subject | Attitude | en |
dc.subject | Double-Blind Method | en |
dc.subject | Face | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Magnetic Resonance Imaging | en |
dc.subject | Male | en |
dc.subject | Photic Stimulation | en |
dc.subject | Prejudice | en |
dc.subject | Propranolol | en |
dc.subject | Temporal Lobe | en |
dc.subject | Whites | en |
dc.subject | Young Adult | en |
dc.title | β-Adrenoceptor blockade modulates fusiform gyrus activity to black versus white faces. | en |
dc.type | Journal Article | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/25899791 | en |
plymouth.issue | 16 | en |
plymouth.volume | 232 | en |
plymouth.publication-status | Published | en |
plymouth.journal | Psychopharmacology (Berl) | en |
dc.identifier.doi | 10.1007/s00213-015-3929-7 | en |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA04 Psychology, Psychiatry and Neuroscience | |
dc.publisher.place | Germany | en |
dcterms.dateAccepted | 2015-03-30 | en |
dc.identifier.eissn | 1432-2072 | en |
dc.rights.embargoperiod | Not known | en |
rioxxterms.versionofrecord | 10.1007/s00213-015-3929-7 | en |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | en |
rioxxterms.licenseref.startdate | 2015-08 | en |
rioxxterms.type | Journal Article/Review | en |