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dc.contributor.authorStone, WJR
dc.contributor.authorCampo, JJ
dc.contributor.authorOuédraogo, AL
dc.contributor.authorMeerstein-Kessel, L
dc.contributor.authorMorlais, I
dc.contributor.authorDa, D
dc.contributor.authorCohuet, A
dc.contributor.authorNsango, S
dc.contributor.authorSutherland, CJ
dc.contributor.authorvan de Vegte-Bolmer, M
dc.contributor.authorSiebelink-Stoter, R
dc.contributor.authorvan Gemert, G-J
dc.contributor.authorGraumans, W
dc.contributor.authorde Jong, RM
dc.contributor.authorFabra-García, A
dc.contributor.authorBradley, J
dc.contributor.authorRoeffen, W
dc.contributor.authorLasonder, Edwin
dc.contributor.authorGremo, G
dc.contributor.authorSchwarzer, E
dc.contributor.authorJanse, CJ
dc.contributor.authorSingh, SK
dc.contributor.authorTheisen, M
dc.contributor.authorFelgner, P
dc.contributor.authorMarti, M
dc.contributor.authorDrakeley, C
dc.contributor.authorSauerwein, R
dc.contributor.authorBousema, T
dc.contributor.authorJore, MM
dc.date.accessioned2018-02-13T12:35:12Z
dc.date.available2018-02-13T12:35:12Z
dc.date.issued2018-02-08
dc.identifier.issn2041-1723
dc.identifier.issn2041-1723
dc.identifier.other558
dc.identifier.urihttp://hdl.handle.net/10026.1/10770
dc.description.abstract

<jats:title>Abstract</jats:title><jats:p>Infection with <jats:italic>Plasmodium</jats:italic> can elicit antibodies that inhibit parasite survival in the mosquito, when they are ingested in an infectious blood meal. Here, we determine the transmission-reducing activity (TRA) of naturally acquired antibodies from 648 malaria-exposed individuals using lab-based mosquito-feeding assays. Transmission inhibition is significantly associated with antibody responses to Pfs48/45, Pfs230, and to 43 novel gametocyte proteins assessed by protein microarray. In field-based mosquito-feeding assays the likelihood and rate of mosquito infection are significantly lower for individuals reactive to Pfs48/45, Pfs230 or to combinations of the novel TRA-associated proteins. We also show that naturally acquired purified antibodies against key transmission-blocking epitopes of Pfs48/45 and Pfs230 are mechanistically involved in TRA, whereas sera depleted of these antibodies retain high-level, complement-independent TRA. Our analysis demonstrates that host antibody responses to gametocyte proteins are associated with reduced malaria transmission efficiency from humans to mosquitoes.</jats:p>

dc.format.extent558-
dc.format.mediumElectronic
dc.languageen
dc.language.isoen
dc.publisherNature Publishing Group
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBurkina Faso
dc.subjectCameroon
dc.subjectCase-Control Studies
dc.subjectFemale
dc.subjectGambia
dc.subjectHumans
dc.subjectImmunoglobulin G
dc.subjectMalaria, Falciparum
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPlasmodium falciparum
dc.titleUnravelling the immune signature of Plasmodium falciparum transmission reducing immunity
dc.typejournal-article
dc.typeJournal Article
dc.typeResearch Support, Non-U.S. Gov't
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000424451300003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue1
plymouth.volume9
plymouth.publication-statusPublished online
plymouth.journalNature Communications
dc.identifier.doi10.1038/s41467-017-02646-2
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
dc.publisher.placeEngland
dcterms.dateAccepted2017-12-15
dc.identifier.eissn2041-1723
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1038/s41467-017-02646-2
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-02-08
rioxxterms.typeJournal Article/Review


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