Unravelling the immune signature of Plasmodium falciparum transmission reducing immunity
dc.contributor.author | Stone, WJR | |
dc.contributor.author | Campo, JJ | |
dc.contributor.author | Ouédraogo, AL | |
dc.contributor.author | Meerstein-Kessel, L | |
dc.contributor.author | Morlais, I | |
dc.contributor.author | Da, D | |
dc.contributor.author | Cohuet, A | |
dc.contributor.author | Nsango, S | |
dc.contributor.author | Sutherland, CJ | |
dc.contributor.author | van de Vegte-Bolmer, M | |
dc.contributor.author | Siebelink-Stoter, R | |
dc.contributor.author | van Gemert, G-J | |
dc.contributor.author | Graumans, W | |
dc.contributor.author | de Jong, RM | |
dc.contributor.author | Fabra-García, A | |
dc.contributor.author | Bradley, J | |
dc.contributor.author | Roeffen, W | |
dc.contributor.author | Lasonder, Edwin | |
dc.contributor.author | Gremo, G | |
dc.contributor.author | Schwarzer, E | |
dc.contributor.author | Janse, CJ | |
dc.contributor.author | Singh, SK | |
dc.contributor.author | Theisen, M | |
dc.contributor.author | Felgner, P | |
dc.contributor.author | Marti, M | |
dc.contributor.author | Drakeley, C | |
dc.contributor.author | Sauerwein, R | |
dc.contributor.author | Bousema, T | |
dc.contributor.author | Jore, MM | |
dc.date.accessioned | 2018-02-13T12:35:12Z | |
dc.date.available | 2018-02-13T12:35:12Z | |
dc.date.issued | 2018-02-08 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.other | 558 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/10770 | |
dc.description.abstract |
<jats:title>Abstract</jats:title><jats:p>Infection with <jats:italic>Plasmodium</jats:italic> can elicit antibodies that inhibit parasite survival in the mosquito, when they are ingested in an infectious blood meal. Here, we determine the transmission-reducing activity (TRA) of naturally acquired antibodies from 648 malaria-exposed individuals using lab-based mosquito-feeding assays. Transmission inhibition is significantly associated with antibody responses to Pfs48/45, Pfs230, and to 43 novel gametocyte proteins assessed by protein microarray. In field-based mosquito-feeding assays the likelihood and rate of mosquito infection are significantly lower for individuals reactive to Pfs48/45, Pfs230 or to combinations of the novel TRA-associated proteins. We also show that naturally acquired purified antibodies against key transmission-blocking epitopes of Pfs48/45 and Pfs230 are mechanistically involved in TRA, whereas sera depleted of these antibodies retain high-level, complement-independent TRA. Our analysis demonstrates that host antibody responses to gametocyte proteins are associated with reduced malaria transmission efficiency from humans to mosquitoes.</jats:p> | |
dc.format.extent | 558- | |
dc.format.medium | Electronic | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Nature Publishing Group | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Burkina Faso | |
dc.subject | Cameroon | |
dc.subject | Case-Control Studies | |
dc.subject | Female | |
dc.subject | Gambia | |
dc.subject | Humans | |
dc.subject | Immunoglobulin G | |
dc.subject | Malaria, Falciparum | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Plasmodium falciparum | |
dc.title | Unravelling the immune signature of Plasmodium falciparum transmission reducing immunity | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Research Support, Non-U.S. Gov't | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000424451300003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 1 | |
plymouth.volume | 9 | |
plymouth.publication-status | Published online | |
plymouth.journal | Nature Communications | |
dc.identifier.doi | 10.1038/s41467-017-02646-2 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
dc.publisher.place | England | |
dcterms.dateAccepted | 2017-12-15 | |
dc.identifier.eissn | 2041-1723 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1038/s41467-017-02646-2 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2018-02-08 | |
rioxxterms.type | Journal Article/Review |