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dc.contributor.authorKenshole, AV
dc.contributor.authorGallichan, D
dc.contributor.authorPahl, Sabine
dc.contributor.authorClibbens, J
dc.date.accessioned2018-01-30T14:55:55Z
dc.date.available2018-01-30T14:55:55Z
dc.date.issued2017-12
dc.identifier.issn1360-2322
dc.identifier.issn1468-3148
dc.identifier.urihttp://hdl.handle.net/10026.1/10694
dc.description.abstract

<jats:sec><jats:title>Background</jats:title><jats:p>Lifestyle has previously been associated with the onset of Alzheimer's disease (AD) in the typically developing population, but research investigating this association in Down syndrome (DS) is limited.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>Adults with DS and AD (<jats:italic>n </jats:italic>=<jats:italic> </jats:italic>27) were compared to adults with DS without AD (<jats:italic>n </jats:italic>=<jats:italic> </jats:italic>30) on physical activity, diet, weight, where participants currently lived, where participants had lived for the majority of their lives, educational attainment, occupational attainment and cognitive activity.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>There was a significant difference between samples on where participants currently lived, with the majority of the clinical sample living in institutionalized settings and the majority of the control sample living in independent/supported living settings. This may reflect a tendency to move people once they start to deteriorate which, if correct, is contrary to clinical recommendations that people with AD should be supported to “die in place.”</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Further research into the way in which lifestyle factors, particularly living environment, could contribute to the increased risk of AD in adults with DS is required. This may support interventions aimed at preventing or delaying the onset of the disease.</jats:p></jats:sec>

dc.format.extent58-66
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoen
dc.publisherWiley
dc.subjectAlzheimer's disease
dc.subjectDown syndrome
dc.subjectdementia
dc.subjectintellectual disabilities
dc.subjectlifestyle
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAlzheimer Disease
dc.subjectCognition
dc.subjectDown Syndrome
dc.subjectFemale
dc.subjectHumans
dc.subjectLife Style
dc.subjectMale
dc.subjectMiddle Aged
dc.titleLifestyle factors and Alzheimer's disease in people with Down syndrome
dc.typejournal-article
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/28758309
plymouth.issueS1
plymouth.volume30
plymouth.publication-statusPublished online
plymouth.journalJournal of Applied Research in Intellectual Disabilities
dc.identifier.doi10.1111/jar.12369
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA04 Psychology, Psychiatry and Neuroscience
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA04 Psychology, Psychiatry and Neuroscience/UoA04 Psychology, Psychiatry and Neuroscience MANUAL
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Centre for Brain, Cognition and Behaviour (CBCB)
plymouth.organisational-group/Plymouth/Research Groups/Centre for Brain, Cognition and Behaviour (CBCB)/Behaviour
plymouth.organisational-group/Plymouth/Research Groups/Institute of Health and Community
plymouth.organisational-group/Plymouth/Users by role
dc.publisher.placeEngland
dcterms.dateAccepted2017-04-24
dc.rights.embargodate2019-7-30
dc.identifier.eissn1468-3148
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1111/jar.12369
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-12
rioxxterms.typeJournal Article/Review


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