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dc.contributor.authorPhillips, Den
dc.contributor.authorCholeris, Een
dc.contributor.authorErvin, KSJen
dc.contributor.authorFureix, Cen
dc.contributor.authorHarper, Len
dc.contributor.authorReynolds, Ken
dc.contributor.authorNiel, Len
dc.contributor.authorMason, GJen
dc.date.accessioned2017-12-12T17:56:10Z
dc.date.available2017-12-12T17:56:10Z
dc.date.issued2016-03-15en
dc.identifier.urihttp://hdl.handle.net/10026.1/10412
dc.description.abstract

Stereotypic behaviour (SB) occurs in certain human disorders (e.g. autism), and animals treated with stimulants or raised in impoverished conditions, including laboratory mice in standard cages. Dysfunctional cortico-basal ganglia pathways have been implicated in these examples, but for cage-induced forms of SB, the relative roles of ventral versus dorsal striatum had not been fully ascertained. Here, we used immunohistochemical staining of FosB and ΔFosB to assess long-term activation within the nucleus accumbens and caudate-putamen of C57BL/6 mice. Housed in typical laboratory cages, these mice spontaneously developed different degrees of route-tracing, bar-mouthing and other forms of SB (spending 0% to over 50% of their active time budgets in this behaviour). The most highly stereotypic mice showed the most elevated FosB/ΔFosB activity in the nucleus accumbens. No such patterns occurred in the caudate-putamen. The cage-induced SB common in standard-housed mice thus involves elevated activity within the ventral striatum, suggesting an aetiology closer to compulsive gambling, eating and drug-seeking than to classic amphetamine stereotypies and other behaviours induced by motor loop over-activation.

en
dc.format.extent238 - 242en
dc.languageengen
dc.language.isoengen
dc.subjectAbnormal repetitive behaviouren
dc.subjectCaudate-putamenen
dc.subjectNucleus accumbensen
dc.subjectStereotypic behaviouren
dc.subjectStereotypyen
dc.subjectStriatumen
dc.subjectTranscription factoren
dc.subjectΔFosBen
dc.subjectAnimalsen
dc.subjectCell Counten
dc.subjectFemaleen
dc.subjectHousing, Animalen
dc.subjectImmunohistochemistryen
dc.subjectMice, Inbred C57BLen
dc.subjectMice, Inbred DBAen
dc.subjectMotor Activityen
dc.subjectNeuronsen
dc.subjectNucleus Accumbensen
dc.subjectProto-Oncogene Proteins c-fosen
dc.subjectSpecies Specificityen
dc.subjectStereotyped Behavioren
dc.titleCage-induced stereotypic behaviour in laboratory mice covaries with nucleus accumbens FosB/ΔFosB expression.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/26731014en
plymouth.volume301en
plymouth.publication-statusPublisheden
plymouth.journalBehav Brain Resen
dc.identifier.doi10.1016/j.bbr.2015.12.035en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Health and Human Sciences
plymouth.organisational-group/Plymouth/Faculty of Health and Human Sciences/School of Psychology
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Biological and Marine Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA04 Psychology, Psychiatry and Neuroscience
dc.publisher.placeNetherlandsen
dcterms.dateAccepted2015-12-20en
dc.identifier.eissn1872-7549en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1016/j.bbr.2015.12.035en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-03-15en
rioxxterms.typeJournal Article/Reviewen


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