Molecular cloning of a gene encoding a 20S proteasome beta subunit from Plasmodium falciparum.
Adenosine TriphosphatasesAmino Acid SequenceAnimalsCloning, MolecularCysteine EndopeptidasesHumansMiceMolecular Sequence DataMultienzyme ComplexesPlasmodium falciparumProteasome Endopeptidase ComplexProtein ConformationRatsSequence AlignmentXenopus laevisZebrafish
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A novel gene was cloned from Plasmodium falciparum. Database searches indicated this gene to be a member of the 20S proteasome beta-subunit family. Comparison of the gene's genomic DNA sequence with cDNA sequence revealed a 156-bp intron 85 bp downstream from the start codon. The nucleotide sequence of the gene contains one open reading frame encoding 265 amino acids with a predicted molecular mass of 30.9 kDa and a pI of 6.2. Northern blot analysis showed the transcript size to be approximately 1.6 kb indicating that some 800 bp of the transcript is non-coding.
Place of Publication
Int J Parasitol
729 - 733
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