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dc.contributor.authorLi, J-Len
dc.contributor.authorHarris, ALen
dc.date.accessioned2017-11-27T16:23:46Z
dc.date.available2017-11-27T16:23:46Z
dc.date.issued2007-06en
dc.identifier.issn1535-6108en
dc.identifier.urihttp://hdl.handle.net/10026.1/10304
dc.description.abstract

Angiogenesis is a hallmark of solid tumors, and disruption of tumor vasculature is an active anticancer therapy in some cases. Several proteins expressed on the surface of tumor endothelium have been identified during the last decade. However, due to the expression in both physiological and tumor angiogenesis, only a few targets have been developed for clinical therapeutics. By thorough SAGE analysis of mouse endothelial cells isolated from various normal resting tissues, regenerating liver, and liver-metastasized tumor, Seaman and colleagues in this issue of Cancer Cell have demonstrated organ-specific endothelial markers, physiological angiogenesis endothelial markers, and tumor endothelial markers and revealed striking differences between physiological and pathological angiogenesis.

en
dc.format.extent478 - 481en
dc.languageengen
dc.language.isoengen
dc.subjectAngiogenesis Inhibitorsen
dc.subjectAnimalsen
dc.subjectBiomarkers, Tumoren
dc.subjectEndotheliumen
dc.subjectLiveren
dc.subjectLiver Neoplasms, Experimentalen
dc.subjectLiver Regenerationen
dc.subjectMiceen
dc.subjectNeovascularization, Pathologicen
dc.subjectNeovascularization, Physiologicen
dc.subjectOrgan Specificityen
dc.titleThe potential of new tumor endothelium-specific markers for the development of antivascular therapy.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/17560330en
plymouth.issue6en
plymouth.volume11en
plymouth.publication-statusPublisheden
plymouth.journalCancer Cellen
dc.identifier.doi10.1016/j.ccr.2007.05.004en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine/UoA01 Clinical Medicine
dc.publisher.placeUnited Statesen
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1016/j.ccr.2007.05.004en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.typeJournal Article/Reviewen


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