WAP four-disulfide core domain protein 2 promotes metastasis of human ovarian cancer by regulation of metastasis-associated genes.
dc.contributor.author | Chen, Y | en |
dc.contributor.author | Huang, L | en |
dc.contributor.author | Wang, S | en |
dc.contributor.author | Liu, T | en |
dc.contributor.author | Wu, Y | en |
dc.contributor.author | Li, J-L | en |
dc.contributor.author | Li, M | en |
dc.date.accessioned | 2017-11-27T15:06:57Z | |
dc.date.available | 2017-11-27T15:06:57Z | |
dc.date.issued | 2017-07-05 | en |
dc.identifier.uri | http://hdl.handle.net/10026.1/10284 | |
dc.description.abstract |
BACKGROUND: WAP four-disulfide core domain protein 2 (WFDC2) shows a tumor-restricted upregulated pattern of expression in ovarian cancer. METHODS: In this study, we evaluated the role of WFCD2 in tumor mobility, invasion and metastasis of ovarian cancer in clinical tissue and in ovarian cancer cells, both in vitro and in vivo. RESULTS: Our results revealed WFCD2 was overexpressed in ovarian tissues, and the expression level of WFCD2 was associated with metastasis and lymph node metastasis. Higher expression of WFCD2 was also observed in aggressive HO8910-PM cells than in HO8910 cells, and WFCD2 knockdown halted cell migration, invasion, tumorigenicity and metastasis in ovarian cancer cells, both in vitro and in vivo. Knockdown of WFDC2 induced the down-regulation of ICAM-1, CD44, and MMP2. CONCLUSION: In summary, our work demonstrates that WFCD2 promotes metastasis in ovarian cancer. These findings suggest that WFCD2 plays a critical role in promoting metastasis and may constitute a potential therapeutic target of ovarian cancer. | en |
dc.format.extent | 40 - ? | en |
dc.language | eng | en |
dc.language.iso | eng | en |
dc.subject | Cell migration and invasion; | en |
dc.subject | Metastasis | en |
dc.subject | Ovarian cancer | en |
dc.subject | WFCD2 | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Animals | en |
dc.subject | Cell Line, Tumor | en |
dc.subject | Cell Movement | en |
dc.subject | Cell Proliferation | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Female | en |
dc.subject | Gene Expression Regulation, Neoplastic | en |
dc.subject | Gene Knockdown Techniques | en |
dc.subject | Heterografts | en |
dc.subject | Humans | en |
dc.subject | Hyaluronan Receptors | en |
dc.subject | Intercellular Adhesion Molecule-1 | en |
dc.subject | Matrix Metalloproteinase 2 | en |
dc.subject | Mice | en |
dc.subject | Middle Aged | en |
dc.subject | Neoplasm Grading | en |
dc.subject | Neoplasm Metastasis | en |
dc.subject | Neoplasm Staging | en |
dc.subject | Ovarian Neoplasms | en |
dc.subject | Proteins | en |
dc.subject | WAP Four-Disulfide Core Domain Protein 2 | en |
dc.title | WAP four-disulfide core domain protein 2 promotes metastasis of human ovarian cancer by regulation of metastasis-associated genes. | en |
dc.type | Journal Article | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/28679402 | en |
plymouth.issue | 1 | en |
plymouth.volume | 10 | en |
plymouth.publication-status | Published online | en |
plymouth.journal | J Ovarian Res | en |
dc.identifier.doi | 10.1186/s13048-017-0329-0 | en |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine/UoA01 Clinical Medicine | |
dc.publisher.place | England | en |
dcterms.dateAccepted | 2017-04-24 | en |
dc.identifier.eissn | 1757-2215 | en |
dc.rights.embargoperiod | Not known | en |
rioxxterms.versionofrecord | 10.1186/s13048-017-0329-0 | en |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | en |
rioxxterms.licenseref.startdate | 2017-07-05 | en |
rioxxterms.type | Journal Article/Review | en |