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Gene expression analysis in human breast cancer associated blood vessels.

Jones, DT; Lechertier, T; Mitter, R; Herbert, JMJ; Bicknell, R; Jones, JL; Li, J-L; Buffa, F; Harris, AL; Hodivala-Dilke, K (2012)

Angiogenesis is essential for solid tumour growth, whilst the molecular profiles of tumour blood vessels have been reported to be different between cancer types. Although presently available anti-angiogenic strategies are ...

Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancer.

Mohd Nafi, SN; Generali, D; Kramer-Marek, G; Gijsen, M; Strina, C; Cappelletti, M; Andreis, D; Haider, S; Li, J-L; Bridges, E; Capala, J; Ioannis, R; Harris, AL; Kong, A (2014-08-15)

The role of HER4 in breast cancer is controversial and its role in relation to trastuzumab resistance remains unclear. We showed that trastuzumab treatment and its acquired resistance induced HER4 upregulation, cleavage ...

Role of hypoxia-inducible factors in epigenetic regulation via histone demethylases.

Yang, J; Ledaki, I; Turley, H; Gatter, KC; Montero, J-CM; Li, J-L; Harris, AL (2009-10)

Eukaryotic chromatin is subject to multiple posttranslational histone modifications such as acetylation, methylation, phosphorylation, and ubiquitination. These various covalent modifications have been proposed to constitute ...

Roles of tetrahydrobiopterin in promoting tumor angiogenesis.

Chen, L; Zeng, X; Wang, J; Briggs, SS; O'Neill, E; Li, J; Leek, R; Kerr, DJ; Harris, AL; Cai, S (2010-11)

Nitric oxide (NO), which is derived from endothelial NO synthase (eNOS), provides crucial signals for angiogenesis in the tumor microenvironment. Tetrahydrobiopterin (BH4) is an absolute requirement for eNOS activity. In ...

Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer.

Leung, W-Y; Roxanis, I; Sheldon, H; Buffa, FM; Li, J-L; Harris, AL; Kong, A (2015-03-20)

Acquired resistance to lapatinib, an inhibitor of EGFR and HER2 kinases, is common. We found that reactivation of EGFR, HER2 and HER3 occurred within 24 hours of lapatinib treatment after their initial dephosphorylation. ...

Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival.

Pike, LRG; Singleton, DC; Buffa, F; Abramczyk, O; Phadwal, K; Li, J-L; Simon, AK; Murray, JT; Harris, AL (2013-01-15)

Hypoxia in the microenvironment of many solid tumours is an important determinant of malignant progression. The ISR (integrated stress response) protects cells from the ER (endoplasmic reticulum) stress caused by severe ...

A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.

Masiero, M; Simões, FC; Han, HD; Snell, C; Peterkin, T; Bridges, E; Mangala, LS; Wu, SY-Y; Pradeep, S; Li, D; Han, C; Dalton, H; Lopez-Berestein, G; Tuynman, JB; Mortensen, N; Li, J-L; Patient, R; Sood, AK; Banham, AH; Harris, AL; Buffa, FM (2013-08-12)

Limited clinical benefits derived from anti-VEGF therapy have driven the identification of new targets involved in tumor angiogenesis. Here, we report an integrative meta-analysis to define the transcriptional program ...

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

Raval, RR; Lau, KW; Tran, MGB; Sowter, HM; Mandriota, SJ; Li, J-L; Pugh, CW; Maxwell, PH; Harris, AL; Ratcliffe, PJ (2005-07)

Defective function of the von Hippel-Lindau (VHL) tumor suppressor ablates proteolytic regulation of hypoxia-inducible factor alpha subunits (HIF-1alpha and HIF-2alpha), leading to constitutive activation of hypoxia pathways ...

DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo.

Li, J-L; Sainson, RCA; Oon, CE; Turley, H; Leek, R; Sheldon, H; Bridges, E; Shi, W; Snell, C; Bowden, ET; Wu, H; Chowdhury, PS; Russell, AJ; Montgomery, CP; Poulsom, R; Harris, AL (2011-09-15)

Resistance to VEGF inhibitors is emerging as a major clinical problem. Notch signaling has been implicated in tumor angiogenesis. Therefore, to investigate mechanisms of resistance to angiogenesis inhibitors, we transduced ...

Role of Delta-like 4 in Jagged1-induced tumour angiogenesis and tumour growth.

Oon, CE; Bridges, E; Sheldon, H; Sainson, RCA; Jubb, A; Turley, H; Leek, R; Buffa, F; Harris, AL; Li, J-L (2017-06-20)

Delta-like 4 (DLL4) and Jagged1 (JAG1) are two key Notch ligands implicated in tumour angiogenesis. They were shown to have opposite effects on mouse retinal and adult regenerative angiogenesis. In tumours, both ligands ...