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Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1.

Jiao, R; Bachrati, CZ; Pedrazzi, G; Kuster, P; Petkovic, M; Li, J-L; Egli, D; Hickson, ID; Stagljar, I (2004-06)

Bloom's syndrome (BS) is a genomic instability disorder characterized by cancer susceptibility. The protein defective in BS, BLM, belongs to the RecQ family of DNA helicases. In this study, we found that BLM interacts with ...

Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D).

Braybrooke, JP; Li, J-L; Wu, L; Caple, F; Benson, FE; Hickson, ID (2003-11-28)

Bloom's syndrome (BS) is a genetic disorder associated with short stature, fertility defects, and a predisposition to the development of cancer. BS cells are characterized by genomic instability; in particular, a high rate ...