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Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts.

Kumar, K; Wigfield, S; Gee, HE; Devlin, CM; Singleton, D; Li, J-L; Buffa, F; Huffman, M; Sinn, AL; Silver, J; Turley, H; Leek, R; Harris, AL; Ivan, M (2013-06)

Inhibition of vascular endothelial growth factor increases response rates to chemotherapy and progression-free survival in glioblastoma. However, resistance invariably occurs, prompting the urgent need for identification ...