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Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition.

Ledaki, I; McIntyre, A; Wigfield, S; Buffa, F; McGowan, S; Baban, D; Li, J-L; Harris, AL (2015-08-14)

Carbonic anhydrase IX (CAIX) is strongly induced by hypoxia and its overexpression is associated with poor therapeutic outcome in cancer. Here, we report that hypoxia promotes tumour heterogeneity through the epigenetic ...