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DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo.

Li, J-L; Sainson, RCA; Oon, CE; Turley, H; Leek, R; Sheldon, H; Bridges, E; Shi, W; Snell, C; Bowden, ET; Wu, H; Chowdhury, PS; Russell, AJ; Montgomery, CP; Poulsom, R; Harris, AL (2011-09-15)

Resistance to VEGF inhibitors is emerging as a major clinical problem. Notch signaling has been implicated in tumor angiogenesis. Therefore, to investigate mechanisms of resistance to angiogenesis inhibitors, we transduced ...