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Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy.

McIntyre, A; Patiar, S; Wigfield, S; Li, J-L; Ledaki, I; Turley, H; Leek, R; Snell, C; Gatter, K; Sly, WS; Vaughan-Jones, RD; Swietach, P; Harris, AL (2012-06-01)

PURPOSE: Bevacizumab, an anti-VEGFA antibody, inhibits the developing vasculature of tumors, but resistance is common. Antiangiogenic therapy induces hypoxia and we observed increased expression of hypoxia-regulated genes, ...