Now showing items 1-2 of 2
DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo.
Resistance to VEGF inhibitors is emerging as a major clinical problem. Notch signaling has been implicated in tumor angiogenesis. Therefore, to investigate mechanisms of resistance to angiogenesis inhibitors, we transduced ...
Role of Delta-like 4 in Jagged1-induced tumour angiogenesis and tumour growth.
Delta-like 4 (DLL4) and Jagged1 (JAG1) are two key Notch ligands implicated in tumour angiogenesis. They were shown to have opposite effects on mouse retinal and adult regenerative angiogenesis. In tumours, both ligands ...