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Nuclear and membrane expression of the angiogenesis regulator delta-like ligand 4 (DLL4) in normal and malignant human tissues.

Martinez, JC; Müller, MM; Turley, H; Steers, G; Choteau, L; Li, J-L; Sainson, R; Harris, AL; Pezzella, F; Gatter, KC (2009-04)

AIMS: Delta-like ligand 4 (DLL4) is one of five known Notch ligands in mammals and interacts predominantly with Notch 1. DLL4 is induced by vascular endothelial growth factor (VEGF) and acts downstream of VEGF as a 'brake' ...

Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer.

Jubb, AM; Turley, H; Moeller, HC; Steers, G; Han, C; Li, J-L; Leek, R; Tan, EY; Singh, B; Mortensen, NJ; Noguera-Troise, I; Pezzella, F; Gatter, KC; Thurston, G; Fox, SB; Harris, AL (2009-11-17)

BACKGROUND: Delta-like ligand 4 (Dll4) is a Notch ligand that is upregulated by hypoxia and vascular endothelial growth factor-A (VEGF-A) and is reported to have a role in tumor angiogenesis. Evidence from xenograft studies ...