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Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species.

Affourtit, C; Jastroch, M; Brand, MD (2011-03-01)

Glucose-stimulated insulin secretion (GSIS) by pancreatic β cells is regulated by mitochondrial uncoupling protein-2 (UCP2), but opposing phenotypes, GSIS improvement and impairment, have been reported for different ...

Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria.

Parker, N; Affourtit, C; Vidal-Puig, A; Brand, MD (2008-05-15)

Leak of protons into the mitochondrial matrix during substrate oxidation partially uncouples electron transport from phosphorylation of ADP, but the functions and source of basal and inducible proton leak in vivo remain ...