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Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancer.

Mohd Nafi, SN; Generali, D; Kramer-Marek, G; Gijsen, M; Strina, C; Cappelletti, M; Andreis, D; Haider, S; Li, J-L; Bridges, E; Capala, J; Ioannis, R; Harris, AL; Kong, A (2014-08-15)

The role of HER4 in breast cancer is controversial and its role in relation to trastuzumab resistance remains unclear. We showed that trastuzumab treatment and its acquired resistance induced HER4 upregulation, cleavage ...