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Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer.

Jubb, AM; Turley, H; Moeller, HC; Steers, G; Han, C; Li, J-L; Leek, R; Tan, EY; Singh, B; Mortensen, NJ; Noguera-Troise, I; Pezzella, F; Gatter, KC; Thurston, G; Fox, SB; Harris, AL (2009-11-17)

BACKGROUND: Delta-like ligand 4 (Dll4) is a Notch ligand that is upregulated by hypoxia and vascular endothelial growth factor-A (VEGF-A) and is reported to have a role in tumor angiogenesis. Evidence from xenograft studies ...