Search

Now showing items 1-2 of 2

Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition.

Ledaki, I; McIntyre, A; Wigfield, S; Buffa, F; McGowan, S; Baban, D; Li, J-L; Harris, AL (2015-08-14)

Carbonic anhydrase IX (CAIX) is strongly induced by hypoxia and its overexpression is associated with poor therapeutic outcome in cancer. Here, we report that hypoxia promotes tumour heterogeneity through the epigenetic ...

Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts.

Kumar, K; Wigfield, S; Gee, HE; Devlin, CM; Singleton, D; Li, J-L; Buffa, F; Huffman, M; Sinn, AL; Silver, J; Turley, H; Leek, R; Harris, AL; Ivan, M (2013-06)

Inhibition of vascular endothelial growth factor increases response rates to chemotherapy and progression-free survival in glioblastoma. However, resistance invariably occurs, prompting the urgent need for identification ...