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Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function.

Patel, NS; Li, J-L; Generali, D; Poulsom, R; Cranston, DW; Harris, AL (2005-10-01)

The Notch signaling pathway and the delta-like 4 ligand (DLL4) play key roles in embryonic vascular development. Many of the pathways involved in embryonic vascular development also play important roles in tumor angiogenesis. ...

Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer.

Patel, NS; Dobbie, MS; Rochester, M; Steers, G; Poulsom, R; Le Monnier, K; Cranston, DW; Li, J-L; Harris, AL (2006-08-15)

PURPOSE: Angiogenesis and vascular endothelial growth factor (VEGF) expression are associated with a poor outcome in bladder cancer. To understand more about the mechanisms, we studied the role of delta-like 4 (DLL4), an ...