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MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU.

Favaro, E; Ramachandran, A; McCormick, R; Gee, H; Blancher, C; Crosby, M; Devlin, C; Blick, C; Buffa, F; Li, J-L; Vojnovic, B; Pires das Neves, R; Glazer, P; Iborra, F; Ivan, M; Ragoussis, J; Harris, AL (2010-04-26)

BACKGROUND: Hypoxia in cancers results in the upregulation of hypoxia inducible factor 1 (HIF-1) and a microRNA, hsa-miR-210 (miR-210) which is associated with a poor prognosis. METHODS AND FINDINGS: In human cancer cell ...

Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts.

Kumar, K; Wigfield, S; Gee, HE; Devlin, CM; Singleton, D; Li, J-L; Buffa, F; Huffman, M; Sinn, AL; Silver, J; Turley, H; Leek, R; Harris, AL; Ivan, M (2013-06)

Inhibition of vascular endothelial growth factor increases response rates to chemotherapy and progression-free survival in glioblastoma. However, resistance invariably occurs, prompting the urgent need for identification ...