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Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo.

Fejer, G; Drechsel, L; Liese, J; Schleicher, U; Ruzsics, Z; Imelli, N; Greber, UF; Keck, S; Hildenbrand, B; Krug, A; Bogdan, C; Freudenberg, MA (2008-11)

The early systemic production of interferon (IFN)-alphabeta is an essential component of the antiviral host defense mechanisms, but is also thought to contribute to the toxic side effects accompanying gene therapy with ...

Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity.

Martin, SF; Dudda, JC; Bachtanian, E; Lembo, A; Liller, S; Dürr, C; Heimesaat, MM; Bereswill, S; Fejer, G; Vassileva, R; Jakob, T; Freudenberg, N; Termeer, CC; Johner, C; Galanos, C; Freudenberg, MA (2008-09-01)

Allergic contact hypersensitivity (CHS) is a T cell-mediated inflammatory skin disease. Interleukin (IL)-12 is considered to be important in the generation of the allergen-specific T cell response. Loss of IL-12 function ...