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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

Raval, RR; Lau, KW; Tran, MGB; Sowter, HM; Mandriota, SJ; Li, J-L; Pugh, CW; Maxwell, PH; Harris, AL; Ratcliffe, PJ (2005-07)

Defective function of the von Hippel-Lindau (VHL) tumor suppressor ablates proteolytic regulation of hypoxia-inducible factor alpha subunits (HIF-1alpha and HIF-2alpha), leading to constitutive activation of hypoxia pathways ...