Browsing 01 University of Plymouth Research Outputs by Subject "Zebrafish"
Now showing items 1-8 of 8
-
Combining motion analysis and microfluidics--a novel approach for detecting whole-animal responses to test substances.
(United States, 2014)Small, early life stages, such as zebrafish embryos are increasingly used to assess the biological effects of chemical compounds in vivo. However, behavioural screens of such organisms are challenging in terms of both ... -
Dynamic transcriptomic profiles of zebrafish gills in response to zinc depletion.
(England, 2010-10-08)BACKGROUND: Zinc deficiency is detrimental to organisms, highlighting its role as an essential micronutrient contributing to numerous biological processes. To investigate the underlying molecular events invoked by zinc ... -
Dynamic transcriptomic profiles of zebrafish gills in response to zinc supplementation.
(England, 2010-10-11)BACKGROUND: Dietary zinc supplementation may help to promote growth, boost the immune system, protect against diabetes, and aid recovery from diarrhoea. We exploited the zebrafish (Danio rerio) gill as a unique vertebrate ... -
Effects of metal nanoparticles on the lateral line system and behaviour in early life stages of zebrafish (Danio rerio).
(Netherlands, 2014-07)The unique physicochemistry and potential toxicity of manufactured nanoparticles (NPs) requires innovative approaches for the assessment of toxicity to aquatic organisms. Here, the toxicity of Cu-NPs, Ag-NPs and TiO2-NPs ... -
Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis.
(England, 2015-09-03)Hypoxia is a common feature of locally advanced breast cancers that is associated with increased metastasis and poorer survival. Stabilisation of hypoxia-inducible factor-1α (HIF1α) in tumours causes transcriptional changes ... -
Lactobacillus rhamnosus lowers zebrafish lipid content by changing gut microbiota and host transcription of genes involved in lipid metabolism.
(England, 2015-03-30)The microbiome plays an important role in lipid metabolism but how the introduction of probiotic communities affects host lipid metabolism is poorly understood. Using a multidisciplinary approach we addressed this knowledge ... -
Probiotic treatment reduces appetite and glucose level in the zebrafish model.
(England, 2016-01-05)The gut microbiota regulates metabolic pathways that modulate the physiological state of hunger or satiety. Nutrients in the gut stimulate the release of several appetite modulators acting at central and peripheral levels ... -
Uptake epithelia behave in a cell-centric and not systems homeostatic manner in response to zinc depletion and supplementation.
(England, 2014-01)Much remains to be understood about systemic regulation of zinc uptake in vertebrates, and adequate zinc status is far from always achieved in animals or human. In addition to absorbing zinc from the diet, fish are able ...
