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dc.contributor.authorGoldsworthy, S
dc.contributor.authorLeslie-Dakers, M
dc.contributor.authorHiggins, S
dc.contributor.authorBarnes, T
dc.contributor.authorJankowska, P
dc.contributor.authorDogramadzi, S
dc.contributor.authorLatour, Jos M
dc.date.accessioned2017-11-17T17:09:20Z
dc.date.available2017-11-17T17:09:20Z
dc.date.issued2017-10-21
dc.identifier.issn1939-8654
dc.identifier.issn1876-7982
dc.identifier.urihttp://hdl.handle.net/10026.1/10203
dc.description.abstract

PURPOSE: The purpose of the article was to determine the impact of Dual Registration (DR) image-guided radiotherapy (IGRT) on clinical judgement and treatment delivery for patients with oropharyngeal cancer before implementation. METHODS: Ninety cone beam computed tomography images from 10 retrospective patients were matched using standard clipbox registration (SCR) and DR. Three IGRT specialist radiographers performed all registrations and evaluated by intraclass correlation to determine inter-rater agreement, Bland-Altman with 95% limits of agreement to determine differences between SCR and DR procedures, changes in clinical judgment, time taken to perform registrations, and radiographer satisfaction. RESULTS: Inter-rater agreement between radiographers using both SCR and DR was high (0.867 and 0.917, P ≤ .0001). The 95% limits of agreement between SCR and DR procedures in the mediolateral, cranial-caudal, and ventrodorsal translational directions were -6.40 to +4.91, -7.49 to +6.05, and -7.00 to +5.44 mm, respectively. The mediolateral direction demonstrated significant proportional bias (P ≤ .001) suggesting non-agreement between SCR and DR. Eighty percent of DR matches resulted in a change in clinical judgement to ensure maximum target coverage. Mean registration times for SCR and DR were 94 and 115 seconds, respectively, and radiographers found DR feasible and satisfactory. CONCLUSION: The standard method using SCR in patients with oropharyngeal cancer underestimates the deviation in the lower neck. In these patients, DR is an effective IGRT tool to ensure target coverage of the inferior neck nodes and has demonstrated acceptability to radiotherapy clinical practice.

dc.format.extent377-384
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoen
dc.publisherElsevier BV
dc.subjectDual registration
dc.subjectcritical structure avoidance
dc.subjecthead and neck radiotherapy
dc.subjectmultiple regions of interest
dc.subjectreproducibility
dc.subjectstability
dc.subjectsystematic and random errors
dc.subjectAged
dc.subjectCone-Beam Computed Tomography
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectOropharyngeal Neoplasms
dc.subjectPilot Projects
dc.subjectRadiotherapy, Image-Guided
dc.subjectRetrospective Studies
dc.titleA Pilot Study Evaluating the Effectiveness of Dual-Registration Image-Guided Radiotherapy in Patients with Oropharyngeal Cancer
dc.typejournal-article
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/31047473
plymouth.issue4
plymouth.volume48
plymouth.publication-statusPublished
plymouth.journalJournal of Medical Imaging and Radiation Sciences
dc.identifier.doi10.1016/j.jmir.2017.09.004
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Nursing and Midwifery
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Health and Community
plymouth.organisational-group/Plymouth/Research Groups/Plymouth Institute of Health and Care Research (PIHR)
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeUnited States
dcterms.dateAccepted2017-09-01
dc.rights.embargodate2018-10-21
dc.identifier.eissn1876-7982
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1016/j.jmir.2017.09.004
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-10-21
rioxxterms.typeJournal Article/Review


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